Radiology of Thalassemia

ISBN-13: 9783642725890 / Angielski / Miękka / 2011 / 154 str.

Constantin Papavasiliou; Theophanis Cambouris; Phaedon Fessas

Opis

Estimates reveal that there are some 200 million heterozygous carriers of abnormal hemoglobins genes worldwide, and tens of thousands of severely affected patients. Effective application of imaging techniques is essential to combat the continuing development of the disease and to ensure risk-free follow-up of the chronically ill. This is the first book to offer complete coverage of such radiologic applications with both conventional and the most modern imaging modalities. Interventional radiology, marrow transplantation, prenatal diagnosis by ultrasonography, and radiotherapy for bone marrow heterotopia are also featured.

Spis treści

I General.- 1 Introduction.- 2 Thalassemia: Basic Genetics and Molecular Defects.- 3 Thalassemia: Pathophysiology, Clinical and Laboratory Findings.- II Imaging.- 4 Radiological Bone Changes in Thalassemia Major.- 5 Osseous X-Ray Findings in Thalassemia Minor.- 6 A Reappraisal of Some Skeletal Changes in Currently Treated ?-Thalassemia.- 7 Grading System of Osseous Changes in Thalassemia.- 8 Computed Tomography Evaluation of the Upper Abdomen in ?-Thalassemia.- 9 Scintigraphic Evaluation of Organ Dysfunction in Thalassemia.- 10 Abdominal Ultrasonography in ?-Thalassemia.- 11 Cardiac Complications in Thalassemia Syndromes: Clinical and Radiological Considerations.- 12 Radiological Aspects of Marrow Heterotopia in Thalassemia.- 13 Magnetic Resonance Imaging of Marrow Heterotopia in the Hemoglobinopathies.- III Management and Prevention.- 14 Effect of Radiotherapy on Symptoms due to Marrow Heterotopia in ?-Thalassemia.- 15 Bone Marrow Transplantation for Thalassemia Major: The Place of Irradiation.- 16 Partial Splenic Embolization in the Management of Thalassemia.- 17 Ultrasound-Guided Procedures for Prenatal Diagnosis of Hemoglobinopathies.