Radioactive Isotopes in Clinical Medicine and Research

ISBN-13: 9783034873420 / Angielski / Miękka / 2012 / 454 str.

H. Bergmann; Helmut Sinzinger

Opis

With the present Badgastein Symposium "Radioactive Isotopes in Clinical Medicine and Research" we have now had 40 years of an uninterrupted series of Badgastein meetings on nuclear medicine, since the first one took place in January 1954. We believe that this anni- versary is worth mentioning. The 21 st symposium proved again to offer a representative cross- section through the current topics of scientific interest of nuclear medicine. The general theme of research in nuclear medicine has shifted from the spectacular new developments which were so often reported in the first symposia to a less spectacular, albeit equally important period, which may best be characterized by validation and standardization. While this may not be as exciting as we would like it to be, it is nevertheless vital for nuclear medicine to maintain and improve its standing amongst the other specialties of medicine which draw upon the services that nuclear medicine offers.

Spis treści

The Badgastein Lecture.- Nuclear Medicine — Tool or Specialty?.- Lung: Therapy.- Ventilation scintigraphy of the tympanic cavity by 133Xenon.- Assessment of lung injury with 67Gallium in patients with pulmonary edema. A preliminary analysis.- A model for administered 81Krm activity and a method for measurement: Some recommendations for patient and staff dose reduction.- Dosimetry of intralesional 131I-monoclonal antibody (MAb) therapy in patients with recurrent high grade gliomas.- Improved control of malignant gliomas by means of intralesional radioimmunotherapy.- Oncology.- Thrombocytopenia in HIV, idiopathic thrombocytopenic purpura (ITP), vasculitis and toxic bone marrow injury: An etiologic entity? Results of a comparative study.- 67Ga scintigraphy, MRI and CT in the follow-up of malignant lymphoma patients with residual mediastinal mass.- Tumor imaging using a 99mTc-labelled immunomodulator — results of clinical studies in various kinds of malignant tumors.- Investigation of breast cancer with 18fluordeoxyglucose (FDG) using conventional gamma camera system and SPECT-technique.- Comparison of 123I-?-methyltyrosine SPECT and 11C-L-methionine PET in patients with brain tumors.- Instrumentation; Image Processing.- PET image reconstruction for pharmacokinetic modeling of 5-[18F]fluorouracil in liver tumors.- Effects of distorted PET projection data on the reconstructed image using different reconstruction algorithms.- Noninvasive determination of the arterial input function: General description for an artery surrounded by homogeneous tissue.- Multimodal image registration for radioimmunotherapy. Surface landmark and frame based correlation in patients undergoing intralesional 131I-MAb therapy for recurrent high grade glioma.- Automatic scaling of static ‘analogue-equivalent’ images obtained from digital gamma camera systems.- A method for determination of regional myocardial blood flow (RMBF) considering regional spillover.- Improvement of HMPAO brain SPECT evaluation using a Kalman filtering approach.- Bayesian identification of compartment structures in dynamic scintigraphic data.- Dosimetry in LDR- and HDR-brachytherapy by SPECT measurements of scattered compton photons.- Cardiology; Angiology.- Residual thallium activity in persistent defects after tracer reinjection at rest: A marker of myocardial viability.- Quantitative relation between resting 201thallium SPECT and 18F-fluorodeoxyglucose SPECT in normals.- Viability of the revascularized myocardium.- Positron-SPET imaging with 81rubidium for detection of coronary artery disease using a special design of a 511-keV collimator for the standard gamma camera.- Quantitative lymphoscintigraphy for the evaluation of lymphaticovenous anastomosis (LVA) in treatment of upper limb edema (ULE).- Immunoscintigraphy; Neurology.- Radioimmunoscintigraphy of ovarian tumours with 99mTc-labelled monoclonal antibody-170.- Immunoscintigraphy of colorectal cancer with 99mTc-labelled F(ab’)2 fragments of the anti-CEA MoAb F023C5. First clinical results.- Radioimmunoscintigraphy of malignant melanoma with 99mTc-labelled monoclonal antibody BW 575.- Estimation of brain perfusion by evaluating the angiographic phase of 99mTc-HMPAO-studies.- Acetazolamide increases cardiac output.- HMPAO-SPECT and FDG-PET in Huntington’s Disease: A methodological study comparing the performance of PET with that of a three headed SPECT camera.- Potential usefulness of stabilization methods for 99mTc-HMPAO in cerebral blood flow imaging.- Pharmacokinetics and biodistribution of [123I]?-CIT in humans.- Gastroenterology; Nephrology.- Scintigraphic determination of the functional abnormality in chronic idiopathic constipation.- Is kidney allograft perfusion determined essentially by donor characteristics? Results of a ‘twin study’.- TC/TL-3-D-subtraction-SPECT of parathyroid glands (PTG) in patients with chronic maintenance hemodialysis and secondary hyperparathyroidism (SHPT).- Scatter correction in renal clearance studies with radioiodine-hippuran.- State-of-the-Art Lecture.- The tissue characterisation of malignancy with radionuclide studies.- Radiopharmacology.- Optimized preparation of the dopaminergic receptor ligands 123I-epidepride and 123I-CIT.- 99Tc-labelling and biodistribution of designed molecules 287.- Different uptake of iodo-doxorubicin labelled with 123I in tumour cells of gastric carcinoma being sensitive and resistant to anthracyclines.- The reduction of the liver radioactivity after application of currently used tumour-affine radiopharmaceuticals.- Deoxyglucose uptake in oestrogen-ablated rat mammary tumours.- Interference of patient medication in the radiolabelling of blood cells: in-vitro and in-vivo effects.- Free Papers.- Volumetric analysis of antral motor activity.- 111lndium polyclonal human immunoglobulin G in human and experimental atherosclerosis.- SPECT-quality-control: Evaluating center-of-rotation offset, Y-shift and detector tilt by means of a single, comprehensive test.- Poster Session I: New Techniques.- Acute ethanol-induced changes in cerebral blood flow.- Experimental studies of 123I-labelled iodo-doxorubicin.- Preparation and quality control of 153Samarium-EDTMP for radio-therapy of metastatic bone pain.- Universally valid algorithms for GFR determination requiring a single plasma sample.- Scintigraphic defaecography: Experience with 145 patients.- A PC LAN as a flexible and non-expensive implementation of a PACS.- Scintigraphic prediction of residual lung function following lobectomy: The use of posterior oblique views.- Poster Session II: Oncology.- 99Tcm (V) DMSA and 111In pentetreotide in the detection of malignancies.- Reliable diagnosis of pancreatic adenocarcinoma with 18F-2-FDG-positron-emissiontomography (PET).- Recognition of rhabdo- and leiomyosarcomas by means of 111In-labeled antimyosinantibody fragments — an improvement for the oncologic diagnostic.- Uptake of 4-iodo-doxorubicin labelled with 123I and 99mTc in tumour cells of gastric carcinoma and suprarenal gland carcinoma.- Platelet uptake of 131I-metaiodobenzylguanidine-mechanism, extent and clinical relevance.- Poster Session III: Varia.- Carotid scintigraphy in hypertensive patients with ultrasound images of intimal thickening.- Mean transit time of 111In-DTPA through the CSF-space for the detection of normal pressure hydrocephalus.- Striatal glucose consumption in various choreatic disorders.- The influence of Verapamil on cardiac uptake of 123I-labelled anthracyclines in rabbits.- Thyroglobulin and its meaning for forensic medicine — experiences in studies using an IRMA test.- Imaging of parathyroid adenomas using 99mTechnetium-Sestamibi in an endemic Goiter area.- Author Index.- Keyword Index.