RNA Viruses and Neurological Disorders

ISBN-13: 9781032259567 / Miękka / 2023 / 248 str.

Opis

An accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system. Including the major RNA viruses, their impact on the central nervous system (CNS), and the similarities and differences in pathological outcomes that can be observed.

Spis treści

Chapter 1: Structure and Classification of RNA viruses  Chapter 2: RNA viruses with CNS tropism  Chapter 3: Common Neuropathological features of RNA viruses  Chapter 4: Molecular and cellular alterations underlying neurological outcomes in HIV infection  Chapter 5: Zika virus and CNS  Chapter 6: Neuropathological outcomes in human influenza and respiratory syncytial virus infections  Chapter 7: The vascular route as a possible gateway for central nervous system pathology in SARS-CoV-2 infection  Chapter 8: Mechanisms for entry of RNA viruses into the CNS  Chapter 9: RNA sequencing as a powerful tool to capture virus-induced changes  Chapter 10: Novel methods and technologies for efficient detection of RNA viruses in the human brain  Chapter 11: An insight into the symptomatic treatment modalities for COVID -19  Chapter 12: Innovations in RNA therapeutics and sequencing technology to combat future viral pandemics  Chapter 13: Innovative Therepeutic Efforts for Tackling Future Viral Pandemics

 

O autorze

Sabyasachi Dash, MSc, PhD is currently a Senior Scientist in the Exploratory Research Division at Alexion-AstraZeneca Rare Disease located in New Haven, CT, USA. His work primarily focuses on drug discovery efforts for central nervous system disorders that are rare yet present a high unmet need in the society given their lack of understanding of the disease biology. He completed his postdoctoral training in neurovascular biology in the Department of Pathology and Laboratory Medicine at the Weill Cornell Medical College of Cornell University, New York, New York. His research focused on the development of novel vasoprotective therapeutics for vascular and cerebrovascular diseases by elucidating novel mechanisms regulating blood-brain barrier function in the mammalian brain. His PhD thesis work investigated the molecular mechanisms governing cocaine-induced neurotoxicity and neuroinflammation in the presence of HIV infection, which is of high pathological relevance in patients addicted to drugs of abuse.