RNA Therapeutics

ISBN-13: 9783319885469 / Angielski / Miękka / 2018 / 259 str.

Amanda L. Garner

Spis treści

Computational Tools for Design of Selective Small Molecules Targeting RNA: From Small Molecule Microarrays to Chemical Similarity Searching.- A Modular Approach to the Discovery and Affinity Maturation of Sequence-Selective RNA-Binding Compounds.- Structure-Based Discovery of Small Molecules Binding to RNA.- Approaches for the Discovery of Small Molecule Ligands Targeting microRNAs.- Viral RNA Targets and Their Small Molecule Ligands.- Drugging Pre-mRNA Splicing.- Targeting RNA G-Quadruplexes for Potential Therapeutic Applications.- The Therapeutic Targeting of Long Noncoding RNA.- Messenger RNA as a Novel Therapeutic Approach.