RNA Processing: Disease and Genome-Wide Probing

ISBN-13: 9783319290713 / Angielski / Twarda / 2016 / 326 str.

Eugene Yeo

Opis

Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration. RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm.

Spis treści

Experimental and computational considerations in the study of RNA binding protein-RNA interactions.- Genome-wide approaches for RNA structure probing.- 

Tethered function assays as tools to elucidate the molecular roles of RNA binding proteins.- Single molecule approaches in RNA-protein interactions.- 

RNA dynamics in the control of circadian rhythm.- Roles of RNA binding proteins and post-transcriptional regulation in driving male germ cell development in the mouse.- Regulation of stem cell self‐renewal and oncogenesis by RNA binding proteins.- Controlling the editor: the many roles of RNA binding proteins in regulating A-to-I RNA editing.- Mutations in splicing factors and cancer.- Regulation of tissue-specific alternative splicing: C. elegans as a model system.- RNA Granules and Diseases—A Case Study of Stress Granules in ALS and FTLD.- Post-translational modifications and RNA-binding proteins.

O autorze

Dr. Gene Yeo is a scientist, entrepreneur, inventor and expert in the area of RNA, genomics and neurological diseases.  Dr. Yeo obtained his BS in Chemical Engineering and a BA in Economics from the University of Illinois, Urbana-Champaign. He has a MA in Business Administration from the Rady School of Management at the University of California, San Diego (UCSD).  Dr. Yeo earned his Ph.D. in Computational Neuroscience from the Massachusetts Institute of Technology.  Using comparative genomics and statistical learning theory Dr. Yeo pioneered new computational approaches to attack the problem of splicing and splicing-mediated gene regulation.  In 2008, Dr. Yeo was appointed an Assistant Professor in the Department of Cellular and Molecular Medicine at UCSD.  In 2011, Dr. Yeo was awarded the Alfred P Sloan Fellowship in recognition of his work in computational molecular biology. Dr. Yeo is also an Adjunct Professor at the National University of Singapore and a visiting researcher at the Molecular Engineering Laboratory under Nobel Laureate Sydney Brenner’s auspices.