Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs

ISBN-13: 9781420094978 / Angielski / Twarda / 2009 / 510 str.

Ray H. Liu

Opis

The analysis of drugs and their metabolites in biological media are now expected to routinely achieve 20% accuracy in the ng/mL concentration level. Therefore, the availability and the selection of quality ion-pairs designating the analytes and their isotopically labeled analogs (ILAs) are important considerations in achieving the accuracy of quantitation results. Assisting scientists with this process, Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs provides an extremely valuable reference for labs involved in the analysis of therapeutic and abused drugs. Part One of this comprehensive volume illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantitation. The second section is a systematic compilation of full-scan mass spectra of drugs and their analogs, as parent compounds and as derivatives resulting from various chemical derivatization approaches, commonly encountered in today s labs. Based on the mass spectra data presented in the second section, Part Three provides corresponding tables of ion-pairs which can potentially be adapted to designate the drugs and their isotopic analogs in the analytical processes. Relative quality of these ion-pairs (cross-contribution to the intensity of these ions by their isotopic analogs) is included in these tables. With more than 1500 full-scan mass spectra and quick access data tables, this text represents the authors years of work compiling mass spectra of the many chemical derivatization forms of drugs, their metabolites, and their isotopically labeled counterparts. The unparalleled scope of this compilation makes it a critical one-stop reference for those involved in drug analyses of biological specimens and interpretation of results. "

With more than1500 full scan mass spectra and quick access data tables, this text provides the first such reference for labs involved in the analysis of abused and therapeutic drugs. Part one illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantification. A second part compiles mass spectra, including drugs and their analogs, as parent compounds and as derivatives resulting from those approaches commonly adapted in today’s labs. Based on data from the second part, the third part provides corresponding tables of ion-pairs that can potentially be adapted to designate the drugs and their analogs in the analytical processes.

Spis treści

Isotopically Labeled Analog as Internal Standard for Drug Quantitation — Methodology. Mass Spectra of Commonly Abused Drugs and Their Isotopically Labelled Analogs in Various Derivatization Forms. Cross-Contributions of Ion Intensity Between Analytes and Their Isotopically Labeled Analogs in Various Derivatization Forms. Index.

O autorze

Ray H. Liu is a professor in the Department of Medical Technology at Fooyin University in Taiwan and professor emeritus in the Department of Justice Sciences at the University of Alabama in Birmingham. Sheng-Meng Wang is a professor of forensic science and director of scientific laboratories at Central Police University in Taiwan. Dennis V. Canfield is the manager of the Bioaeronautical Sciences Research Laboratory at the U.S. Federal Aviation Administration’s Civil Aerospace Medical Institute (CAMI) in Oklahoma City, Oklahoma.