Pulmonary Hypertension

ISBN-13: 9781420094756 / Angielski / Twarda / 2009 / 552 str.

Marc Humbert; III Joseph P. Lynch

Opis

Written by internationally recognized experts, Pulmonary Hypertension bridges the gap between pulmonology and cardiology to provide clinicians in both disciplines with knowledge of the signs, symptoms, diagnosis, and pharmacologic and surgical treatments for pulmonary hypertension (PH). Through the use of clinical trials, this ground-breaking text supplies a comprehensive review of both the primary and secondary clinical and investigative aspects of this condition. Discussing controversies and concepts in PH diagnosis and management, this guide explores:

• classification and epidemiology, pathology, pathogenesis, genetics, and diagnosis of PH
• causes of the condition, such as idiopathic pulmonary arterial hypertension (IPAH)
• PAH-complicating connective tissue diseases (CTD), congenital heart diseases, human immunodeficiency virus (HIV), and other disorders
• the mechanisms, toxicities, and efficacy of therapeutic agents
• the role of combination therapies, novel agents, and future directions
• PH in specific patient populations such as pregnant and critically-ill patients in the ICU

Spis treści

1. Classification and Epidemiology of Pulmonary Hypertension. 2. Pathology of Pulmonary Hypertension. 3. Pathogenesis of Pulmonary Arterial Hypertension (PAH). 4. Animal Models of Pulmonary Hypertension. 5. Genetics of PAH. 6. Imaging of Pulmonary Hypertension. 7. Echocardiography of PAH. 8. Diagnosis and Hemodynamic Assessment of PAH. 9. Idiopathic PAH. 10. PAH Complicating Connective Tissue Diseases. 11. PAH in Congenital Heart Diseases. 12. PAH and HIV Infection. 13. Portopulmonary Hypertension. 14. Pulmonary Hypertension Complicating Schistosomiasis. 15. Hemolysis-Associated Pulmonary Hypertension. 16. Pulmonary Veno-Occlusive Disease and Pulmonary Capillary Hemangiomatosis. 17. Pulmonary Hypertension in Obstructive Lung Diseases. 18. Pulmonary Hypertension in Restrictive Lung Diseases. 19. Chronic Mountain Sickness. 20. Chronic Thromboembolic Pulmonary Hypertension. 21. Medical Treatment of PAH: Basic Therapy and Calcium Channel Blockers. 22. Medical Treatment of PAH: Prostacyclins. 23. Medical Treatment of PAH: Phosphodiesterase Inhibitors. 24. Medical Treatment of PAH: Endothelin Receptor Antagonists. 25. Medical Treatment of PAH: Combination Therapy, Novel Agents, Future Directions and Current Recommendations. 26. Atrioseptostomy in PAH. 27. Surgical Management of PAH. 28. Lung Transplantation for Pulmonary Hypertension: Who Is a Candidate and When to List? 29. Pregnancy and PAH. 30. Management of PAH in the ICU. 31. End Points and Clinical Trial Designs in PAH: Clinical and Regulatory Perspectives.

O autorze

Marc Humbert, Joseph P. Lynch III