Pathobiology of Necrosis.- Types of Chronic Wounds: Indications for Enzymatic Débridement.- Why Wounds Need to Be Débrided.- Surgical Versus Enzymatic Débridement.- Evaluation of Wound Débridement Using Computerized Image Analysis.- Types of Enzymes on the Market.- The Role of Collagenase in Wound Healing.- Collagenase, Aid for Treatment of Decubitus Ulcers.- Future Prospects of Proteolytic Enzymes and Wound Healing.