Protein Structure : Determination, Analysis, and Applications for Drug Discovery

ISBN-13: 9780824740320 / Angielski / Twarda / 2003 / 576 str.

Daniel Chasman; Chasman Chasman; Daniel Chasman

Opis

This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. It covers numerous high-throughput technologies as well as computational methods to study protein structures and residues.

Spis treści

Structural biology and structural genomics - a federal agency perspective, John C. Norvell and Marvin Cassman; determination; producing proteins, Aled M. Edwards, Cheryl H. Arrowsmith, Raymond Hui, Fabien Marino, Alexei Savchenko, Ken Yamazaki, and Adelinda Yee; crystallization of membrane proteins, R. Michael Garavito; prospects for high-throughput structure determination by X-ray crystallography, Frank von Delft, Charles D. Kang, and Duncan E. McRee; prospects for high-throughput structure determination of proteins by NMR spectroscopy, Ann E. Ferentz; automated molecular replacement, Jorge Navaza and Pedro M. Alzar; comparative protein structure modelling, Andras Fiser and Andrej Sali; rising accuracy of protein secondary structure prediction, Burkhard Rost; novel fold and ab initio methods for protein structure generation, David J. Osguthorpe; analysis; identifying errors in three-dimensional protein models, Brian D. Marsden and Ruben A. Abagyan; comparative analysis and evolutionary classification of protein structures, Liisa Holm; automated genome functional annotation for structural genomics, Sophia Tsoka and Christos A. Ouzounis; the importance of structure-based function annotation to drug discovery, Susan M. Baxter, Stacy Knutson, and Jacquelyn S. Fetrow; the protein data bank, Helen M. Berman, Philip E. Bourne, John Westbrook, and Christine Zardecki; the European bioinformatics Institute macromolecular structure database (E-MSD), Dimitris Dimitropoulos, Peter A. Keller, Kim Henrick, John Ionides, Eugene Krissinel, Philip McNeil, and Sameer S. Velankar; applications for drug discovery; molecular docking in structure-based design, Trevor W. Heritage; use of pharmacophores in structure-based drug design, Omoshile Clement and Adrea T. Mehl; the structure of human interferon- -1a (Avonexr) and its relation to activity - a Case study of the use of structural data in the arena of protein pharmaceuticals, Adrian Whitty and Michael Karpusas; G-protein- coupled rece

O autorze

Daniel I. Chasman