Protein Kinases in Development and Disease: Volume 123

ISBN-13: 9780128015131 / Angielski / Twarda / 2017 / 498 str.

Andreas Jenny

Opis

Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease.

• Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms
• Includes a broad scope of topics that are addressed
• Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge

Spis treści

1. WNK Kinases in Development and Disease 2. SGK1: The Dark Side of PI3K Signaling 3. Homeodomain-Interacting Protein Kinases: Diverse and Complex Roles in Development and Disease 4. ROR-Family Receptor Tyrosine Kinases 5. Regulation of Drosophila Development by the Golgi Kinase Four-Jointed 6. The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease 7. Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor 8. Glycogen Synthase Kinase 3: A Kinase for All Pathways? 9. CK1 in Developmental Signaling: Hedgehog and Wnt 10. Ligand Receptor-Mediated Regulation of Growth in Plants 11. Regulation of Cell Polarity by PAR-1/MARK Kinase 12. Receptor Tyrosine Kinases and Phosphatases in Neuronal Wiring: Insights From Drosophila 13. VEGF Receptor Tyrosine Kinases: Key Regulators of Vascular Function

O autorze

Andreas Jenny currently is Associate Professor in the departments of Developmental and Molecular Biology and Genetics at the Albert Einstein College of Medicine in New York. He received his PhD from the University of Basel, Switzerland for his work on mRNA 3'end processing with Dr. W. Keller. He then joined the lab of Dr. Anne Ephrussi at the EMBL in Heidelberg to study how mRNA localization leads to embryonic axis determination. In Anne's lab, he realized how great Drosophila is to address fundamental questions of development. While in the lab of Dr. Marek Mlodzik at Mount Sinai in New York, Dr. Jenny started to combine molecular in vitro and genetic in vivo approaches to study the regulation of the canonical and non-canonical Wnt pathways. His own lab at Einstein focuses on kinases that regulate Wnt signaling and mediate its interactions with the cytoskeleton. More recently the Jenny lab also became interested in autophagy with the overarching goal to use Drosophila as model system to address fundamental questions that are relevant for development and disease in general.