Protein Homology Detection Through Alignment of Markov Random Fields: Using Mrfalign

ISBN-13: 9783319149134 / Angielski / Miękka / 2015 / 51 str.

Jinbo Xu; Sheng Wang; Jianzhu Ma

Opis

This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.

Spis treści

Introduction

Method

Software

Experiments and Results

Conclusion