Proteases, Protease Inhibitors and Protease-Derived Peptides: Importance in Human Pathophysiology and Therapeutics

ISBN-13: 9783034873994 / Angielski / Miękka / 2012 / 248 str.

J. Cheronis;Repine

Opis

Proteases, Protease-Derived Peptides and Protease Inhibitors Many physiological as weil as pathophysiological processes are mediated by proteases and the products of their actions, protease-derived peptides. However, the uncontrolled activity of proteases can be extraordinarily destructive and dangerous to normal biologie systems. As a result, biology has gone to great lengths to control the activities of the proteases involved in these systems by developing aseries of both highly specific (regulatory) and non-specific (protective) anti-proteases. The protease/anti-protease balancing activities include the normal homeostatic processes of clotting and clot lysis, hormonal regulation of blood pressure and the control of the inflammatory response represented by both the humoral (the kallikrein-kinin and complement systems) and cellular (neutrophil and macrophage derived proteases) components of the inflammation. Examples of successful therapies directed at these protease dependent systems include the use of warfarin and heparin to control thrombosis and streptokinase or tissue plasminogen activator (tPA) for the acceleration of clot dissolution. Similarly, the use of angiotensin converting enzyme (ACE, a type of limited activity protease or peptidase) inhibitors has made a significant impact on the treatment of hypertension. Lastly, the restitution of normal antiprotease levels by the infusion of the purified protein in patients with genetic alpha-1-antiprotease deficiency is regularly being used to reduce the rate of lung function 1055 caused by the unopposed activity of human neutrophil elastase in these individuals.

Spis treści

Overview.- Proteases — Structures, Mechanisms and Inhibitors.- Biochemical Mechanisms for Disrupting the Proteinase-Proteinase Inhibitor Balance in Tissues.- Oxidants, Metalloproteases and Serine Proteases in Inflammation.- Elastase and Oxygen Radicals: Synergistic Interactions.- Neutrophil Elastase Inhibitors: Clinical Potential.- Proteolysis-Induced Pathomechanisms in Acute Inflammation and Related Therapeutic Approaches.- Synthesis and Characterization of Human Neutrophil Elastase Inhibitors Derived from Aromatic Esters of Phenylalkanoic Acids.- In Vivo Evaluation of MDL 201,404YA, A Novel Inhibitor of Human Neutrophil Elastase.- Alpha1-Antitrypsin Augmentation Therapy.- Secretory Leukocyte Protease Inhibitor in Cystic Fibrosis.- Oxidation Resistant Muteins of Antileukoproteinase as Potential Therapeutic Agents.- Proteases and Protease-Derived Peptides in Inflammation.- Factor XII Activation and Inhibition in Inflammation.- The Kinin System in Inflammation.- Role of Bradykinin in Microbial Infection: Enhancement of Septicemia by Microbial Proteases and Kinin.- Kinin Antagonists as Human Therapeutics.- Proteases in Immunoregulation and Cellular Differentiation.- Cytokine Regulation of Endothelial Cell Extracellular Proteolysis.- Different Functional Share of Individual Lysosomal Cathepsins in Normal and Pathological Conditions.- Neuropeptide Processing in Pathophysiology.- Resolution of limp-Free and Timp-Complexed 70kDa Progelatinase from Culture Medium of Rous Sarcoma Virus-Transformed Chicken.- Endotoxin and Eicosanoids.