1. Introductory words: cell metabolism and systems biology2. Introduction to prostate cancer metabolism and treatment with nonconventional drugs3A. The conductors of the metabolic orchestra: part I3B. Phosphatase and tensin homolog deleted in chromosome 10: another metabolic regulator in prostate cancer?4. Lipid metabolism part I: an overview5. Lipid metabolism part II: sphingolipids and ceramides6. Fatty acid synthesis and prostate cancer7. Cholesterol metabolism in prostate cancer8. Glutamine metabolism in prostate cancer9. Carbohydrate metabolism in prostate cancer10. pH and electrolytes metabolism in prostate cancer11. Iron metabolism in prostate cancer12. Androgen metabolism in castration-resistant prostate cancer13. Summary, discussion, and conclusions