Progress in Regional Cancer Therapy

ISBN-13: 9783642748202 / Angielski / Miękka / 2011 / 322 str.

Raimund Jakesz; Hugo Rainer

Opis

Present knowledge in regional cancer therapy is presented in this volume. The latest research addresses the questions of optimal drug development, the best galenic form and schedule to control tissue distribution at the tumor site and efficient treatment of specific anatomical regions.

Spis treści

Advances in Drug Delivery.- Advances in Drug Delivery to Cancer Patients: Introduction.- Technical Developments in the Delivery of Antineoplastic Agents.- Is There a Pharmacologic Rationale for Continuous Cancer Chemotherapy?.- Central Venous Access in Children Through a Fully Implantable Drug Delivery System.- Intraportal Chemotherapy for Colorectal Hepatic Metastases.- Liver Metastases.- Prophylactic and Adjuvant Regional Chemotherapy of the Liver in Colorectal Malignancies.- Randomized Multicenter Trial on Adjuvant Intraportal Chemotherapy for Colorectal Cancer (SAKK 40/81).- Enhancement of Cytotoxic Efficacy of 5-Deoxy-5-fluorouridine in Acetoxymethyl-methylnitrosamine-Induced Colorectal Adenocarcinomas in SD Rats by Locoregional Administration into the Inferior Mesenteric Artery.- Second Hepatic Resections in Patients with Liver Metastases from Colorectal Carcinoma.- Six Years of Experience with Local Chemotherapy of the Liver.- Regional Therapy of Hepatic Metastases: Prognostic Factors.- Regional Therapy with 5-Fluorouracil: Dependence of Systemic Concentrations on the Infusion Rate.- Combined Regional and Systemic Chemotherapy in Hepatic Metastases of Colorectal Carcinoma: Continuous IA Vs Simultaneous IA/IV FUDR Infusion.- Intra-arterial Chemotherapy of Liver Metastases.- Current Standards and Limits in Treatment of Hepatic Metastases.- Degradable Starch Microspheres in Intra-arterial Tumor Treatment: An Overview.- Increasing the Uptake of a Low Molecular Weight Marker in Liver Tumours by Degradable Starch Microspheres: Possible Mechanisms of Action.- Dextrane Particle Use in Regional Chemotherapy: Problems of Monitoring.- Chemoembolization of Hepatic Tumors with Degradable Starch Microspheres.- Head and Neck Tumors.- Cytostatic Treatment of Advanced Squamous Cell Carcinoma of the Maxillofacial Region.- A Complex Chemotherapeutic Concept in the Treatment of Oral Carcinomas with Cisplatin and 5-Fluorouracil.- Pathological Assessment of the Results of Intra-arterial Chemotherapy for Head and Neck Carcinomas by Serial Sections of the Whole Specimen.- The Bypass Method in Head and Neck Cancer.- Intratumoral Treatment of Incurable Head and Neck Cancer with Recombinant Human Tumor Necrosis Factor-?.- Preoperative Local Immunotherapy with OK-432 (Picibanil) in Patients with Squamous Cell Cancer of the Oral Cavity.- Extremity Tumors.- Intra-arterial Chemotherapy, Preoperative and Postoperative Radiotherapy, and Surgery for Primary “Unresectable” High-Grade Soft Tissue Sarcomas of the Extremities.- Regional Induction Chemotherapy Followed by Radiotherapy and/or Surgery in Management of Large and Aggressive Sarcomas in Shoulder, Pelvis and Limbs.- Neo-adjuvant Chemotherapy for Osteosarcoma of the Extremities: The Experience at the Rizzoli Institute in 210 Patients Treated with Two Successively Activated Preoperative Protocols Using High-Dose or Moderate-Dose Methotrexate + Cisplatin or High-Dose Methotrexate + Cisplatin + Doxorubicin.- Neo-adjuvant Therapy of Soft Tissue Sarcomas of the Extremities with Intra-arterial Chemotherapy and Radiation.- Melanoma.- Isolation Perfusion for Malignant Melanomas: Established Facts and Parameters to Be Clarified.- Regional Extremity Perfusion in Patients with Malignant Melanoma.- Preliminary Results of a Double Perfusion Schedule with Melphalan in Measurable Melanoma.- Melphalan in Isolated Limb Perfusion for Malignant Melanoma, Bolus for Divided Dose, Tissue Levels, the pH Effect.- Isolation Perfusion of Malignant Soft Tissue Tumors.- Intravesical Therapy.- The Effect of Topical Adriamycin in Superficial Bladder Tumors: A 5-Year Follow-up.- Topical Instillation of Mitomycin C in the Treatment of Superficial Bladder Tumors: Long-Term Observation.- Mitomycin and Hyaluronidase in the Prevention of Recurrent Bladder Tumor.- How Effective is Topical Interferon-?2b for Preventing Recurrence of Superficial Bladder Cancer.- Neo-adjuvant Intra-arterial Chemotherapy for Treatment of Locally Advanced Bladder Cancer: Therapeutic Protocol and Preliminary Report.- Radiotherapy.- Reconstructive Microsurgery and Radiotherapy in Advanced Tumors of the Head and Neck.- Palliation of Nonresectable Esophageal Cancer by Irridium-192 Intraluminal Afterloading.- Interstitial Radiotherapy with Iridium-192 in the Treatment of Early Breast Cancer.- Intracavitary High-Dose-Rate Afterloading Irradiation in the Treatment of Cancer of the Esophagus and Gastroesophageal Junction.- External Radiotherapy for Local and Regional Control of Lung Cancer.- Hyperthermia.- Clinical Experience with a Multifrequency Hyperthermia System and Chemotherapy in the Treatment of Superficial Metastases.- Recent Clinical Experience with an Annular Phased Array Hyperthermia System in the Treatment of Advanced Recurrences in the Pelvis.- The Viennese Interstitial System KHS 9/W 18: Homogenous Hyperthermia with Simultaneous Radiation in Deep-seated Tumors with Integrated Heat Protection of Normal Tissue.- Thermoradiotherapy of Superficial and Half-Deep-seated Tumors: Thermal Profiles and Tumor Response.- Comparison of Leakage Measurement Using 99mTc-Labeled Red Blood Cells and Peripheral Melphalan Determination in Hyperthermic Isolation Perfusion of the Extremities.- Clinical and Histopathological Aspects of Hyperthermic Isolated Regional Perfusion of Soft Tissue Sarcomas of the Extremities.- Laser Therapy.- Experimental Basis of CO2 Laser Application in Tumor Surgery.- Experience with CO2 Laser in Tumor Surgery.- Nd: YAG Laser Application in the Surgical Treatment of Cancer.- Neodymium: YAG Laser Therapy in Gastroduodenal Cancer.- Innovative Approaches.- The Use of Tumor-Infiltrating Lymphocytes in Cancer Therapy.- Adoptive Immunotherapy for Renal Adenocarcinoma: Use of Oxidizing Mitogen-Treated Mononuclear Leukocytes and Continuous Infusion of Interleukin-2.- Processing of Antigen-Antibody Complexes at the Level of the Tumor Cell.- Regional Immunotherapy and Chemotherapy in Lung Cancer.