Progress in Molecular and Subcellular Biology 3

ISBN-13: 9783642655807 / Angielski / Miękka / 2011 / 254 str.

Spis treści

Reverse Transcription and the Central Dogma.- I. Introduction.- II. Cryptology and the Central Dogma.- III. Reverse Transcription: Experimental Evidence.- IV. Reverse Transcription and Cancer.- V. Is There Reverse Transcription in Bacteria?.- VI. Biological Significance of Reverse Transcription.- VII. Cryptography and the Central Dogma.- VIII. Conclusion.- IX. Glossary of Terms.- References.- X. Addendum.- The Isolation of Genes: A Review of Advances in the Enrichment, Isolation and in vitro Synthesis of Specific Cistrons.- I. Introduction.- II. Procedures for the Preparation of Specific Cistrons.- III. Conclusion.- References.- Mechanism of Protein Synthesis and the Use of Inhibitors in the Study of Protein Synthesis.- I. Introduction.- II. Initiation of Protein Synthesis.- III. Chain Elongation.- IV. Chain Termination.- V. Epilogue.- References.- Structural Features of Immunoglobulin Light Chains.- I. Introduction.- II. Association of Light Chains.- III. Thermal Behavior of Bence-Jones Proteins.- IV. Distribution of Polar and Apolar Residues in Amino Acid Sequences of Light Chains.- V. Criteria of Purity in the Bence-Jones Protein Used in the Crystallographic Study.- VI. Crystallography of the Mcg Bence-Jones Protein.- VII. Discussion.- VIII. Summary.- References.- The Thalassemia Syndromes: Genetically Determined Disorders of the Regulation of Protein Synthesis in Eukaryotic Cells.- I. Introduction.- II. The Beta Thalassemias: Clinical Picture and Pathogenesis of Anemia.- III. The Molecular Basis of the Suppression of Beta Chain Synthesis in Severe Beta Thalassemia.- Appendix I: The Alpha Thalassemias.- Appendix II: The Lepore-Pylos Hemoglobins.- References.- The Mitochondrial DNA of Malignant Cells.- I. Introduction.- II. Morphology of Mitochondria in Malignant Cells.- III. Size and Structure of Mitochondrial DNA in Malignant Cells.- IV. Synthesis of Mitochondrial DNA in Malignant Cells: Content, Rate and Mechanism.- V. Is the Informational Content of Mitochondrial DNA Modified in Malignant Cells?.- VI. Are the Changes in Mitochondrial DNA in Malignant Cells Under Genetic Control?.- VII. Are the Changes in Mitochondrial DNA Related to Some Energy Imbalance in Mitochondria of Malignant Cells?.- VIII. Are the Changes Observed in Mitochondrial DNA of Malignant Cells Specific of Malignancy?.- IX. Concluding Remarks.- Appendix I. Isolation and Examination of Mitochondrial DNA.- Appendix II. DNA Circular Oligomers other than Mitochondrial.- References.