Progress in Molecular and Subcellular Biology

ISBN-13: 9783642677038 / Angielski / Miękka / 2012 / 256 str.

T. O. Diener; H. Faulstich; F. Hutchinson

Spis treści

The Photochemistry of 5-Bromouracil and 5-Iodouracil in DNA (With 2 Figures).- A. Introduction.- B. Structural and Spectroscopic Information.- C. Ultraviolet-induced Lesions in DNA Containing BrUra.- D. Biological Effects of BrUra and IUra Photoproducts.- E. Uses of the Photochemistry of Bromouracil in Biology.- F. Differential Staining of Sister Chromatids Containing BrUra 24.- G. Incorporation of Halouracils in DNA.- H. Relationship Between Other Biological Effects of the Halouracils and Photochemical Effects.- References.- Non-Intercalative Binding to DNA (With 2 Figures).- A. Introduction.- B. Poly-L-Lysine.- C. Spermine and Related Polyamines.- D. Distamycin A and Netropsin.- E. Methyl Green.- F. Other Non-Intercalators.- G. Discussion and Conclusions.- References.- The Amatoxins (With 3 Figures).- A. Introduction.- B. Occurrence and Structure.- C. Toxicity.- D. Inhibition of RNA Polymerase in Vitro.- E. Molecular Interaction with RNA Polymerase.- F. Structural Lesions in Nuclei.- G. Lesions Induced in In-Vivo Systems.- H. Penetration into Various Cells.- I. Resistant Cell Lines.- J. Virus Research.- K. Hormonal Research.- L. Developmental Studies.- M. Behavioral Research.- References.- Specialized Genetic Recombination Systems in Bacteria: Their Involvement in Gene Expression and Evolution (With 21 Figures).- A. Introduction.- B. Genetic Recombination: An Overview.- C. Specialized Recombination Systems in Bacteria.- D. Effect of Transposable Elements and Viruses on Bacterial Evolution.- E. Use of Transposable Elements as Experimental Tools.- F. Specialized Recombination in Eukaryotic Cells: A Prologue.- References.- Viroids (With 3 Figures).- A. Introduction.- B. Physical and Chemical Properties of Viroids.- C. Replication of Viroids.- D. Possible Mechanisms of Pathogenesis.- E. Possible Origin of Viroids.- References.