Progress in Drug Research » książka
Progress in Drug Research
ISBN-13: 9783034895446 / Angielski / Miękka / 2012 / 336 str.
Hepatitis C virus (HCV) was first identified in 1989 as the etiologic agent of non-A, non-B hepatitis 1] and is currently recognized as the leading cause of chronic liver disease worldwide. In contrast to hepatitis B virus infection, in which only about 5% of adult infections become chronic, more than 80% of HCV-infected patients develop chronic hepatitis. Moreover, 20-50% of those persistently infected with HCV will develop liver cirrhosis and hepatocellu- lar carcinoma (HCC) 2]. It is estimated that there are 10,000 deaths in the USA per year due to chronic liver failure or HCC 3]. In addition, HCV dis- 25-50% of all liver transplants in US centers, and the ease is responsible for recurrence of HCV infection following liver transplantation is universal 4]. Typically, HCV disease emerges after a 10-20 year period during which symp- toms, if they exist at all, are mild and non-specific. Although the prevalence varies greatly among different countries, it has been estimated that up to 170 million people (3% of the world's population), are infected with HCV 5]. A recent study in the USA found that 65% of all HCV-infected persons are 30 to 49 years old 6].
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