Prognostic value of anti-delta-catenin antibody in precancerous lesions of colorectal cancer

ISBN-13: 9786204341613 / Angielski / Miękka / 60 str.

Ghada Sahraoui

Opis

Introduction: Colorectal cancer by its frequency and severity represents a major health problem in the world. It can develop from precancerous lesions or low to high grade adenomas. Delta-catenin has recently been identified as one of the factors involved in the initiation, promotion and progression of colorectal cancer. Objectives of the work: Our objectives were to evaluate the expression of delta-catenin in low-grade and high-grade adenomas and in colorectal carcinomas and to study the histopronostic factors and the evolution of patients according to the level of expression of delta-catenin by immunohistochemistry. Materials and methods: The anti-delta-catenin antibody is tested, using the immunohistochemistry technique, on 3 groups of 7 patients, selected according to the type of the lesion, collected within the Anatomy department and Pathological cytology of the Salah Azaiz Institute over a period of 16 years (2002-2018). Results: Our results showed that the labeling of tumor cells and the intensity of the labeling were low in low-grade adenomas, moderate in high grade and more intense adenomas.

O autorze

Sahraoui, GhadaName and first name: Sahraoui Ghada Date of birth: 07/30/1986 Nationality: Tunisian Professional situation: Hospital-university assistant in Pathological Anatomy and Cytology Professional address: Department of Anatomy and Pathological Cytology Salah Azaiez Institute Tunis Affiliation: Faculty of Medicine of Tunis State Doctorate in Medicine.