Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action: Held at the Walter

ISBN-13: 9783642651434 / Angielski / Miękka / 2012 / 400 str.

Rhoads, Robert E.

Spis treści

Complexes of Biologically Active Substances with Nucleic Acids — Yesterday, Today, Tomorrow.- Antibiotics and Nucleic Acids.- Kinetics of Binding of Drugs to DNA.- The Binding of Actinomycin D to DNA.- Interaction of Antitumor Antibiotics with DNA: Studies on Sibiromycin.- Anthramyein.- Inhibition of RNA Synthesis by Quinone Antibiotics.- Changes in the Properties of Ribosomes and Transfer RNA Induced by Inhibitors of Protein Synthesis.- Antimalarials and Nucleic Acids.- Chloroquine Binding to Nucleic Acids: Characteristics, Biological Consequences, and a Proposed Binding Model for the interaction.- A Preliminary Nuclear Magnetic Resonance Study of the Effect of pH on the Structure of Chloroquine Diphosphate.- Effects of Chlotoquine and Some Related Compounds on Aminoacylation of Transfer Ribonucleic Acids.- Interaction of Antimalarial Aminoquinolines (Primaquine, Pentaquine, and Chloroquine) with Nucleic Acids, and Effects onVarious Enzymatic Reactions in Vitro.- Interpretation of Antimalarial Activity in Terms of Regression Analyses, Molecular Orbital Calculations, and Theory of DNA-Drug Binding.- Alkaloids, Natural Poly amines and DNA.- Interactions of Alkaloids with DNA.- Physical Studies on the Interaction of Lysergic Acid Diethylamide and Trypanocidal Dyes with DNA and DNA-Containing Genetic Material.- Comments on the Interaction of LSD with DNA.- The Interaction of Polyamines with Nucleic Acids.- Intercalation into Supercoiled DNA.- The Use of Intercalative Dyes in the Study of Closed Circular DNA.- Binding of Drugs to Supercoiled Circular DNA: Evidence for and against Intercalation.- Synthetic Drugs and Dyes Binding to Nucleic Acids.- Mode of Action of Miracil D.- Molecular Biological Effects of Nitroakridin 3582 and Related Compounds.- Binding of Naphthylvinylpyridines to DNA.- Formation of Yeast Mitochondria: V. Ethidium Bromide as a Probe for the Functions of Mitochondrial DNA.- Studies on tRNA Structure Using Covalently and Noncovalently Bound Fluorescent Dyes.- Antimutagens.- Antimutagens and Antimicrobial Drug Resistance.- Some Studies on the Antimutagenic Action of Polyamines.- Carcinogens and Nucleic Acids.- Interaction and Linkage of Polycyclic Hydrocarbons to Nucleic Acids.- Interaction of N-2-Acetylaminofluorene with RNA.- The Natural State of DNA.- Intercalability, the ? Transition, and the State of DNA in Nature.