Prions and Diseases

ISBN-13: 9783031205644 / Angielski / Twarda / 2023 / 793 str.

Wen-Quan Zou; Pierluigi Gambetti

Opis

Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.

Spis treści

Part I: HISTORY

 

Chapter 1   Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek

       Paul Brown

 

Part II: GENERAL ASPECTS OF PRIONS

 

Chapter 2  The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein

                   Glenn L. Millhauser

 

Chapter 3  Mammalian Prion Structures

                   Byron Caughey, Efrosini Artikis, and Allison Kraus

 

Chapter 4  Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein

                   Aggregates in the Brain of Asymptomatic Individuals

                   Wen-Quan Zou

 

Part III: CONVERSION AND STRAIN OF PRIONS

 

Chapter 5   Prion Conversion and Deformed Templating

                    Ilia V. Baskakov

 

Chapter 6   Prion Strain Interference    

                    Ronald A. Shikiya and Jason C. Bartz

 

Chapter 7   Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins

             Lenka Hromadkova, M. Khursheed Siddiqi, He Liu, and Jiri G. Safar

 

Chapter 8   Cofactor Involvement in Prion Propagation

                    Surachai Supattapone and Michael B. Miller

 

Chapter 9    Prion Protein Conversion and Lipids

                     Jiyan Ma and Xiangyi Zhang

 

Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS

 

Chapter 10  Prions in the Environment

                     Shannon L. Bartelt-Hunt, Jason C. Bartz, and Qi Yuan

 

Chapter 11 Environmentally Acquired Transmissible Spongiform Encephalopathy

                    Paul Brown

 

Chapter 12 Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion

             Alexander H. Peden, Marcelo A. Barria

 

Chapter 13 Species Barriers in Prion Disease

                    Suzette A. Priola

 

Part V:  MODELLING OF PRIONS

 

Chapter 14 Modeling the Cell Biology of Prions

                    Richard Rubenstein, David Doyle and Robert B. Petersen

 

Chapter 15 Transgenic Mice Modelling in Prion Diseases

                    Barry Bradford, Neil A. Mabbott and Abigail B. Diack

 

Chapter 16 Stem Cell Models in Prion Research

                    Cathryn Haigh

 

Chapter 17 Drosophila Models of Prion Diseases

                    Ryan R. Myers and Pedro Fernandez-Funez

 Part VI:    HUMAN PRION DISEASES AND OTHER PATHOLOGIES

 

Chapter 18 Human Sporadic Prion Diseases

                    Pierluigi Gambetti and Ignazio Cali

 

Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases

                   James A. Mastrianni

 

Chapter 20 Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies

                    Zerui Wang, Jue Yuan, Tricia Gilliland, Maria Gerasimenko, Syed Zahid Ali Shah, Wen-Quan Zou

 

Chapter 21 The Spectrum of Tau Pathology in Human Prion Disease

                    Gabor G. Kovacs and Herbert Budka

 

Chapter 22  Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease

                    Graham P. Roseman, Li Fu and Stephen M. Strittmatter

 

Chapter 23 Prion and Cancers

             Wei Xin

 

Chapter 24 Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury

                    Zerui Wang and Wen-Quan Zou

 

Part VII: ANIMAL PRION DISEASES

 

Chapter 25  Bovine Spongiform Encephalopathy

                      Gianluigi Zanusso and Salvatore Monaco

 

Chapter 26  Classical and Atypical Scrapie in Sheep and Goats

                     Christine Fast and Martin H. Groschup

 

Chapter 27  Research models for studying chronic wasting disease

                     Julianna Sun and Glenn Telling

 

Part VIII: YEAST PRIONS

 

Chapter 28  Introduction to Yeast and Fungal Prions

                     Reed B. Wickner and Herman K. Edskes

 

Chapter 29  Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems

                     Reed B. Wickner, Herman  K.  Edskes, Moonil Son, Songsong Wu and Madaleine Niznikiewicz

 

Part IX:  DIAGNOSIS AND HUMAN PRION SURVEILLANCE

 

Chapter 30  Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of

                     human prion diseases

                     Christina D. Orrù, Onyekachi Isiofia, Andrew G. Hughson and Byron Caughey

 

Chapter 31  Protein Misfolding Cyclic Amplification

                    Fabio Moda, Sandra Pritzkow, and Claudio Soto

 

Chapter 32  Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases

                     Zerui Wang, Johnny Dang, and Wen-Quan Zou

 

Chapter 33  Diagnosis of Prion Disease: Conventional Approaches

              Inga Zerr and Peter Hermann

 

Chapter 34  Human Prion Disease Surveillance

                     Brian S. Appleby, Lawrence B. Schonberger, Ermias D. Belay

 

Part X: TREATMENT

 

Chapter 35  Overview on Treatment of Prion Diseases and Decontamination of Prions

                     Richard Knight

 

Chapter 36  Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases

                     Manuel Camacho and Qingzhong Kong

Chapter 37  Immunomodulation

                     Thomas Wisniewski and Fernando Goñi

O autorze

Wen-Quan Zou, MD, PhD is Professor of Pathology at Case Western University School of Medicine, and he is Associate Director of the National Prion Disease Pathology Surveillance Center.

 

Pierluigi Gambetti, MD, is Professor of Pathology and Neurology at Case Western University School of Medicine.

Blurb

Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.