Principles of Cancer Treatment and Anticancer Drug Development

ISBN-13: 9783030187248 / Angielski / Miękka / 2020 / 145 str.

Wolfgang Link

Opis

This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

Recenzje

"'Principles of Cancer Treatment and Anticancer Drug Development' provides a welcome introduction to the treatment of cancer and the development of new cancer therapies. Every clinical researcher would benefit from a basic understanding of the treatment and research context of cancer clinical research studies." (Norman M. Goldfarb, Journal of Clinical Research Best Practices, Vol. 16 (2), February, 2020)

Spis treści

Preface

ii          Acknowledgements

iii         Contents

iv       Abbreviations

1. Introduction

2. Cancer Therapy

3. Cancer drug resistance

4. Drug Discovery and Development

5 Economic and social implications of modern drug discovery

Index.

O autorze

Dr. Wolfgang Link is an Assistant Professor at the Universisty of Algarve in the Department of Biomedical Sciences and Medicine. He is also Head of Oncobiology at the Center for Biomedical Research (CBMR).