I. Introduction II. Biochemical and Pharmacological Mechanisms III. Autonomic Physiology IV. Autonomic Response to Environmental Challenges V. Pathophysiological Mechanisms VI. Evaluation of Autonomic Function VII. Cardiovascular Disorders VIII. Congenital Autonomic Disorders IX. Autonomic Synucleinopathies X. Peripheral Autonomic Disorders XI. Autonomic Syndromes XII. Special Clinical Conditions XIII. Management of Neurogenic Orthostatic Hypotension XIV. Autonomic Neuromodulation as a Treatment Strategy XV. Novel Approaches in Autonomic Neuroscience