Primary Hypertension: Basic Mechanisms and Therapeutic Implications

ISBN-13: 9783540163909 / Angielski / Miękka / 1986 / 240 str.

Werner Kaufmann; Gerd Banner; Robert Lang

Opis

Some of the leading scientists in the field of hypertension accepted an invi- tation to actively participate in an international symposium on primary hypertension. Scientists from 13 countries - from western, southern, and eastern Europe, Australia, and the United States - were present. The meeting was held in Cologne in March 1985. After previous meetings and workshops at Titisee in the Black Forest and several symposia on the renin- angiotensin-aldosterone system here in Cologne, this symposium on prima- ry hypertension was organized in order to induce and to stimulate critical discussion on the basic pathogenetic mechanisms involved and the recently established therapeutic implications. Numerous studies have been based on the concept that the elevation in blood pressure is mediated by several vasopressor substances. For this reason the renin-angiotensin system has been considered to be the essential endocrine mechanism involved in developing and sustaining arterial hyper- tension. Other vasopressor factors, such as catecholamines, vasopressin, and serotonin, have been studied extensively and were assumed to play additional parts in blood pressure regulation.However, several other ap- proaches have been initiated in recent years.

Spis treści

Critical Review of Pathogenesis of Primary Hypertension.- Sodium Chloride and Blood Pressure.- Non-Modulating Essential Hypertension: A Subset with Sodium Sensitivity.- Vasodepressor Hormones (Kinins) in Blood Pressure Regulation.- Peripheral Adrenergic Mechanisms in Primary Hypertension.- Neural Transmitters and Central Mechanisms in Primary Hypertension.- Brain Peptides in Cardiovascular Regulation.- Critical Evaluation of Basic Mechanisms of Primary Hypertension. Round Table Discussion.- Principal Objectives of Antihypertensive Treatment.- Treatment of Vascular Damage in Experimental Malignant Hypertension with Nifedipine and Its Calcium-Antagonistic Dihydropyridine Derivatives.- Trends in Arteriosclerosis in Treated and Untreated Hypertensive Patients.- Changes in Brain Blood Flow and Organ Function Following Treatment of Primary Hypertension.- Changes in Hypertrophy by Treatment in Hypertension: Results of Experimental Research.- Reversal of Left Ventricular and Coronary Hypertrophy Following Antihypertensive Treatment.- The Use of the Dynamic Spatial Reconstructor to Study Renal Function.- Critical Review of Antihypertensive Pharmacotherapy.- Cardiovascular Intervention Studies: Problems and Perspectives.- Indications for Antihypertensive Treatment.- Rationale for Established Antihypertensive Treatment.- Calcium Channel Blockers in the Treatment of Hypertension.- Converting Enzyme Inhibitors in the Treatment of Hypertension and of Cardiac Failure.- Serotonin, Serotonergic Antagonists, and Hypertension.- Critical Evaluation of Antihypertensive Pharmacotherapy. Round Table Discussion.