Primary Biliary Cirrhosis: From Pathogenesis to Clinical Treatment

ISBN-13: 9789401060479 / Angielski / Miękka / 2012 / 176 str.

Keith D. Lindor; E. Jenny Heathcote; Raoul E. Poupon

Opis

This volume, the proceedings of a one-day symposium held in Chicago, USA, on November 6, 1997, provides an update for hepatologists, gastroenterologists, and basic scientists with an interest in primary biliary cirrhosis. New insights into the pathogenesis and the natural history of the disease are discussed, and approaches to management of the complications as well as newer therapeutic options are presented by internationally recognized authors. It is intended that this book will help foster new and better approaches for the management of patients with primary biliary cirrhosis.

Spis treści

Preface. Section I: Natural History and Pathogenesis. 1. Natural History and Demography of Primary Biliary Cirrhosis; O.F.W. James. 2. Immune Basis for PBC; M. Bassendine. 3. Isolation and Cloning of Anti-Mitochondrial Antibodies; R. Joplin. 4. Significance of Antimitochondrial Antibody-Profiles in Primary Biliary Cirrhosis; R. Klein, P.A. Berg. 5. Chloride/Bicarbonate Exchange in PBC: A Clue for Pathogenesis? J.F. Medina, J. Prieto. 6. Molecular Considerations of Primary Biliary Cirrhosis; M.E. Gershwin, et al. 7. Animal Models of Primary Biliary Cirrhosis; C.D. Howell, et al. 8. Fibrogenesis in PBC; D. Schuppan, E.G. Hahn. 9. Natural History Models of Primary Biliary Cirrhosis; W.R. Kim, E.R. Dickson. Section II: Management of PBC. 10. Portal Hypertension in Patients with Primary Biliary Cirrhosis; P.M. Huet, et al. 11. Primary Biliary Cirrhosis: From Pathogenesis to Clinical Treatment; A. Parés. 12. Fatigue in the Primary Biliary Cirrhosis Patient; M.G. Swain. 13. The Pruritus of Cholestasis: Behavioral Studies Shed Light on its Pathogenesis; N.V. Bergasa, E.A. Jones. 14. Old and New Immunosuppressant Drugs: Mechanisms and Potential Value; J.M. Vierling. 15. Methotrexate and Colchicine in the Treatment of Primary Biliary Cirrhosis; M.M. Kaplan. 16. Corticosteroids in PBC; H.R. van Buuren. 17. Ursodeoxycholic Acid Treatment of Primary Biliary Cirrhosis: Potential Mechanisms of Action; G. Paumgartner. 18. Ursodiol and Combination Therapy;R.L. Carithers, Jr. 19. Primary Biliary Cirrhosis Transplantation and Recurrent Disease; J. Neuberger. 20. New Clinical Trials in Primary Biliary Cirrhosis: Design and Endpoints; J. Everhart. Index.