Precision Molecular Pathology of Neoplastic Pediatric Diseases

ISBN-13: 9783319896250 / Angielski / Twarda / 2018 / 360 str.

Larissa V. Furtado; Aliya N. Husain

Spis treści

Section I. Molecular Pathology of Pediatric Neoplasms: General Principles

1. Principles of Molecular Biology

1.1. Nucleic acid structure, composition and organization

1.2. Gene structure, organization, expression

1.3. Chromosome structure

1.4. Circulating nucleic acid

1.5. Mitochondrial DNA

2. Molecular Oncogenesis

2.1.

Oncogenes

2.2. Tumor suppressor genes

2.3. Genomic alterations

2.4. Oncogenic viruses

2.5. Genomic landscape of pediatric neoplasms

3. Molecular Testing in Oncology

3.1. Indications

3.2. Considerations for selection of a molecular test

3.3. Ethical considerations

3.4. Specimen requirements

3.5. Specimen collection and processing

3.6. Interpretation of molecular testing results

4. Molecular Methods in Oncology: Targeted Mutational Analysis

4.1. PCR-based techniques

4.2. FISH

5. Molecular Methods in Oncology: Genomic Analysis

5.1. Next-generation sequencing

5.2. Chromosomal microarray

6. Molecular Targeted Therapy of Pediatric Neoplasms

Section II. Molecular Pathology of Specific Pediatric Neoplasms

7. Hematolymphoid System

7.1. Childhood leukemias

7.2. Childhood myelodysplastic syndrome

7.3. Childhood lymphomas

8. Nervous System

8.1. Gliomas

8.1.1. Low-grade gliomas

8.1.2. High-grade gliomas

8.1.3. Diffuse intrinsic pontine glioma

8.2. Astrocytomas

8.2.1. Low-grade astrocytomas

8.2.2. High-grade astrocytoma

8.2.3. Pleomorphic xanthoastrocytoma

8.3. Atypical teratoid rhabdoid tumors

8.4. Ependymoma

8.5. Subependymal giant cell tumor

8.6. Medulloblastoma

8.7. Craniopharyngioma

8.8. Choroid plexus tumors

8.9. Retinoblastoma

9. Neuroblastoma and neuroblastic tumors

10. Skin, Soft Tissue and Bone

10.1. Melanocytic neoplasms

10.2. Langerhans cell histiocytosis

10.3. Nodular fasciitis

10.4. Fibromatosis

10.

5. Rhadomyosarcoma

10.6. Desmoplastic small round cell tumor

10.7. Ewing sarcoma family

10.8. Synovial sarcoma

10.9. Malignant peripheral nerve sheath tumor

10.10. Vascular neoplasms

10.11. Giant cell tumor 

10.12. Aneurysmal bone cyst

10.13. Fibrous dysplasia/McCune-Albright syndrome

10.14. Oste

oblastoma

10.15. Osteosarcoma

10.16. Rare pediatric soft tissue neoplasms

11. Head and Neck

11.1. Salivary gland neoplasms

11.2. Thyroid and parathyroid neoplasms

12. Cardiovascular and Respiratory System

12.1. Pleuropulmonary blastoma

12.2. Inflammatory myofibroblastic tumor

12.3. Histiocytoid cardiomyopathy

13. Gastrointestinal Tract

13.1. Gastrointestinal stromal tumor

13.2. Juvenile polyposis syndrome

13.3. Familial adenomatous polyposis

13.4. Peutz-Jeghers syndrome

13.5. Cronkhite-Canada syndrome

13.6. PTEN hamartoma tumor syndromes

13.7. Cowden syndrome

13.8. Bannayan-Riley-Ruvalcaba syndrome

14. Liver and Pancreas

14.1. Hepatoblastoma

14.2. Hepatocellular carcinoma

14.3. Pancreatoblastoma

15. Genitourinary

15.1. Wilms tumor

15.2. MITF/TFE family translocation-associated carcinoma 

O autorze

Larissa V. Furtado, MD

Medical Director, Molecular Oncology

ARUP Laboratories

Assistant Professor of Pathology

University of Utah School of Medicine

500 Chipeta Way

MS J15-113

Salt Lake City, Utah, 84108

Aliya N. Husain, MD

Professor of Pathology

University of Chicago Medicine

5841 S. Maryland Ave., Room S-627, MC 6101

Chicago, IL 60637 

Blurb

This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care.

Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.