Precision Cancer Medicine: Challenges and Opportunities

ISBN-13: 9783030236366 / Angielski / Twarda / 2020 / 196 str.

Roychowdhury, Sameek

Opis

Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer's unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.

Spis treści

Preface

1: Between Hype and Hope, on the Cutting Edge of Precision Cancer Medicine.

2: Molecular Diagnostics in Cancer: a Fundamental Component of Precision Oncology

3: Clinical Interpretation

4: Precision Cancer Medicine and Clinical Trial Design

5: Resistance to Anti-Cancer Therapeutics

6: Exceptional Responders

7: Immunogenomics

8: Managing Germline Findings from Molecular Testing in Precision Oncology

9: Ethical, legal, and social implications of precision cancer medicine

10: Liquid Biopsy: Translating Minimally Invasive Disease Profiling From The Lab To The Clinic

11: Data Portals and Analysis

Index.

O autorze

Dr. Roychowdhury is a physician scientist in medical oncology focusing on translational cancer genomics and implementing precision cancer medicine. His clinical practice in medical oncology includes patients with advanced, metastatic cancer including prostate, colorectal, and rare cancer subtypes.

Blurb

This comprehensive book was written by leading researchers in the emerging and changing field of precision cancer medicine. Precision cancer medicine entails connecting the right molecular diagnosis to the right treatment plan for individual patients. The textbook covers a range of topics from basic science to clinical application for patient care. Precision cancer medicine includes multi-disciplinary fields of research expertise ranging from genomics, pathology, oncology, hereditary genetics, bioinformatics, immunology, cancer biology, and bioethics.

Basic topics include molecular diagnostics, liquid biopsy, immunogenomics, drug resistance mechanisms, and bioinformatics analyses of big data. The clinical topics include clinical interpretation, hereditary cancers, designs of basket clinical trials, exceptional responders, and the ethical, legal, and social implications of clinical genomics research.

Readers who are involved in one of the specialities of precision cancer medicine can benefit from this book through exposure to other fields. Any level of training or professional practice can benefit from the broad exposure this book can provide.