Practical Pharmacology for Alzheimer's Disease

ISBN-13: 9783319262048 / Angielski / Twarda / 2016 / 141 str.

Takashi Kudo; Kenneth Davis; Rafael Blesa Gonzalez

Opis

In this book, the four leading experts on the ACE inhibitors donepezil, galantamine, and rivastigmine and the NMDA receptor antagonist memantine explain the practical pharmacology of these symptomatic drugs with the aim of providing a sound basis for their clinical use in patients with Alzheimer s disease. In addition, an introductory chapter considers the basic theory of pharmacology for Alzheimer s disease and the book closes with an overview of the ways in which symptomatic drugs for dementia are used. The wide acceptance of the amyloid cascade hypothesis has led to vigorous development of disease-modifying drugs for Alzheimer s disease, such as amyloid vaccinations and gamma- or beta-secretase inhibitors. The failure of clinical trials of these drugs to yield satisfactory results has, however, meant that for the time being patients continue to be treated only with symptomatic drugs. There is accordingly a need to become more proficient in the use of symptomatic medicines, and it is against the background of this quest that Practical Pharmacology for Alzheimer s Disease will be of wide interest. "

Recenzje

"Written by four experts in dementia research, this book describes the pharmacology of the four symptomatic drugs used in the treatment of Alzheimer's disease. It provides an overview of the basic theories of the pharmacology of Alzheimer's disease and the way in which the medications are used for the treatment of dementia. ... book is most suitable for geriatric psychiatrists, geriatric medicine specialists, and neurologists who spend a significant amount of time treating people with Alzheimer's disease and other dementias." (Danielle L. Anderson, Doody's Book Reviews, June, 2016)

Spis treści

Basic theory of pharmacology for Alzheimer’s disease.- Practical Pharmacology of Donepezil.- Practical pharmacology of Galantamine.- Practical pharmacology of Rivastigmine.- Practical Pharmacology of Memantine.- How do we use Symptomatic drugs for Dementia.​

O autorze

Dr. Takashi Kudo, Osaka University Health Care Center, Department of Psychiatry,Toyonaka, Japan

Dr. Kenneth Davis, Mount Sinai Medical Center, New York, NY 10029, USA

Dr. Rafael Blesa Gonzalez, Autonomous University of Barcelona, Barcelona, Spain

Dr. David George Wilkinson, University of Southampton, Southampton, United Kingdom

Blurb

The wide acceptance of the amyloid cascade hypothesis has led to vigorous development of disease-modifying drugs for Alzheimer’s disease, such as amyloid vaccinations and gamma- or beta-secretase inhibitors. However, the fact that clinical trials of these drugs have not yet yielded satisfactory results has meant that for the time being patients continue to be treated only with symptomatic drugs. Currently, four such drugs are available: donepezil, galantamine, rivastigmine, and memantine. In this book, the four leading experts on each of these drugs explain their practical pharmacology with the aim of providing a sound basis for their use, which to date has been of questionable proficiency. In addition, an introductory chapter considers the basic theory of pharmacology for Alzheimer’s disease and the book closes with an overview of the ways in which symptomatic drugs are used for dementia.