Practical Lung Pathology

ISBN-13: 9783031144042 / Angielski / Miękka / 2023

Opis

This text consists of neoplastic and non-neoplastic lung pathology. It discusses frequently encountered issues and diagnostic problems using a Q&A format and case presentations.  Emphasis is placed on differentiating one from another based on the histopathological features, ancillary tests including immunohistochemical and molecular analyses, and clinical and radiologic correlation. In particular, clinical-radiologic-pathologic correlation is emphasized in the diagnosis of interstitial lung disease (ILD).    

This text addresses the issues and diagnostic criteria in segregating a reactive process from adenocarcinoma, poorly differentiated adenocarcinoma from poorly differentiated squamous cell carcinoma, small cell carcinoma from other types of neuroendocrine tumors, large cell carcinoma from large cell neuroendocrine carcinoma, spindle cell/sarcomatoid carcinoma from sarcomatoid mesothelioma, and carcinoma from epithelioid mesothelioma in small biopsy specimens. It also discusses key features useful for differentiating usual interstitial pneumonia (UIP) pattern from non-UIP patterns of ILD such as hypersensitivity pneumonitis, nonspecific interstitial pneumonia, and organizing pneumonia patterns in wedge biopsy specimens as well as highlights the differential diagnosis in the granulomatous inflammation.  

As a whole, this text answers many of the difficult questions relevant to daily practice of lung pathology. Each chapter addresses a specific diagnostic question significantly related to patients’ treatment options. 

Spis treści

Part I. Neoplastic Lung Pathology  

Bronchial Squamous Cell Papilloma versus Squamous Cell Carcinoma

Pulmonary Hamartoma versus Chondroid Neoplasms

Reactive Type II Pneumocyte Hyperplasia versus Adenocarcinoma

Atypical Adenomatous Hyperplasia versus Peribronchiolar Metaplasia

Adenocarcinoma In-Situ versus Atypical Adenomatous Hyperplasia

Invasive Adenocarcinoma versus Adenocarcinoma In-Situ

Solid Pulmonary Adenocarcinoma versus Large Cell Undifferentiated Carcinoma

Large Cell Neuroendocrine Carcinoma versus Solid-Predominant Lung Adenocarcinoma

Poorly Differentiated Squamous Cell Carcinoma versus Solid Pattern Adenocarcinoma

Invasive Mucinous Adenocarcinoma versus Ciliated Muconodular Papillary Tumor

Mucoepidermoid Carcinoma versus Adenosquamous Carcinoma

Large Cell (Undifferentiated) Carcinoma (LCC) versus Large Cell Neuroendocrine Carcinoma (LCNEC)

Large Cell Neuroendocrine Carcinoma versus Small Cell Carcinoma of the Lung

Atypical Carcinoid Tumor versus Large Cell Neuroendocrine Carcinoma

Small Cell Carcinoma versus Atypical Carcinoid Tumor

Typical versus Atypical Carcinoid and Diffuse Idiopathic Neuroendocrine Cell Hyperplasia versus Carcinoid Tumorlets

Minute Meningothelial-Like Nodules versus Tumorlet

Primary Lung versus Metastatic Adenocarcinoma

Metastatic Urothelial Carcinoma versus Squamous Cell Carcinoma

Thymic Carcinoma versus Lung Squamous Cell Carcinoma

Pulmonary Epithelioid Hemangioendothelioma versus Carcinoma and Other Epithelioid Neoplasms

Epithelioid Malignant Mesothelioma versus Adenocarcinoma   

Sarcomatoid Carcinoma versus Sarcomatoid Malignant Mesothelioma

Primary Sarcoma (Unclassified) versus Sarcomatoid Mesothelioma/Carcinoma

Synovial Sarcoma versus Solitary Fibrous Tumor

Inflammatory Myofibroblastic Tumor versus Organizing Pneumonia

Metastatic Malignant Epithelioid Melanoma versus Poorly Differentiated Carcinoma

Pulmonary Epithelioid Angiosarcoma versus Carcinoma

Epithelioid Sarcoma versus Large Cell (Undifferentiated) Carcinoma

Intimal Sarcoma versus Other Spindle Cell Neoplasms

Sclerosing Pneumocytoma versus Lung Adenocarcinoma

 

Erdheim-Chester Disease versus Reactive Inflammatory Infiltrates

Mucosal Marginal Zone Lymphoma versus Follicular Bronchiolitis

Primary Pulmonary Diffuse Large B Cell Lymphoma versus Poorly Differentiated Carcinomas

Lymphomatoid Granulomatosis versus Granulomatosis with Polyangiitis

Primary Pulmonary Classic Hodgkin Lymphoma versus Other Non-Hodgkin Lymphomas

Post-Transplant Lymphoproliferative Disorders in Lung after Lung Transplantation versus Infection and Inflammation

Part II. Non-Neoplastic Lung Pathology

Usual Interstitial Pneumonia versus Non-Specific Interstitial Pneumonia

Hypersensitivity Pneumonitis versus Usual Interstitial Pneumonia

Organizing Pneumonia versus Usual Interstitial Pneumonia

Diffuse Alveolar Damage (Organizing Phase) versus Nonspecific Interstitial Pneumonia

Chronic Eosinophilic Pneumonia versus Organizing Pneumonia

Pulmonary Langerhans Cell Histiocytosis with Fibrosis versus Organizing Pneumonia

 

IgG4-Related Lung Disease versus Other Fibroinflammatory Processes

Pulmonary Alveolar Proteinosis versus Pulmonary Edema

Non-Specific Interstitial Pneumonia versus Lymphoid Interstitial Pneumonia versus Follicular Bronchiolitis

Respiratory Bronchiolitis versus Desquamative Interstitial Pneumonia

Constrictive Bronchiolitis

Granulomatosis with Polyangiitis versus Mycobacterial/Fungal Infection

Eosinophilic Granulomatosis with Polyangiitis versus Eosinophilic Pneumonia

Pulmonary Sarcoidosis versus Mycobacterial/Fungal Disease in the Lung

Histoplasmosis, Blastomycosis, Coccidioidomycosis, and Cryptococcosis in the Lung

Pneumocystis jirovecii Pneumonia versus Histoplasmosis

The Differential Diagnosis of Invasive Mold Infections in the Lung

Primary Pulmonary Arterial Hypertension versus Secondary Pulmonary Hypertension

Pulmonary Capillary Hemangiomatosis versus Congestion

Pulmonary Veno-Occlusive Disease versus Pulmonary Arterial Hypertension

Lymphangioleiomyomatosis versus Benign Metastasizing Leiomyoma

Diffuse Pulmonary Lymphangiomatosis versus Lympangioleiomyomatosis

Intralobar versus Extralobar Pulmonary Sequestration

O autorze

Haodong Xu, MD, PhD

Department of Laboratory Medicine and Pathology

University of Washington Medical Center

1959 NE Pacific St

Seattle WA 98195

Email: xuh8@uw.edu

                  

Robert W. Ricciotti, MD

Department of Laboratory Medicine and Pathology

University of Washington Medical Center

1959 NE Pacific St

Seattle WA 98195

Email: ricciott@uw.edu

Jose G. Mantilla, MD

Department of Laboratory Medicine and Pathology

University of Washington Medical Center

1959 NE Pacific St

Seattle WA 98195

Email: mantilla@uw.edu