Practical Aspects of Vaccine Development

ISBN-13: 9780128143575 / Angielski / Miękka / 2021 / 410 str.

Satoshi Ohtake; Parag Kolhe

Spis treści

Section 1: Formulation Development

1. Overview of vaccine antigens

Katherine Elizabeth Odneal

2. Overview of vaccine adjuvants

Mansoor M. Amiji, Rushit Lodaya, Sonia Gregory and Derek t. O'Hagan

3. Formulation considerations for Live attenuated vaccines

Lee Smith

4. Subunit based vaccines: Challenges in developing protein based vaccines

Charkes Middaugh and Salvador Fernando Ausar

5. Formulation development approaches and considerations for protein based vaccines

Malte Meppen and Daniela Stranges

6. DNA and RNA vaccines

Kanwal Gill, Leanne Minall and Aslin Rodriguez Nassif

7. Antigen-adjuvant formulation- Key considerations

Deep Bhattacharya, Aaron J. Latal, Vamsi Krishna Mudhivarthi and Chris Wiley II

8. Suspension Properties and Characterization of Aluminum-Adjuvanted Vaccines

Alex Langford

Section 2: Process Development

9. Effect of shipping stress on suspension vaccines

Jianxin Guo and Parag Kolhe

10. Developing control strategy for final dose concentration- Case study

Deep Bhattacharya and Parag Kolhe

11. Lyophilized vaccine development

Adora Padilla, Nicole Payton and Rushit Lodaya

Section 3: Delivery

12. Conventional and non-traditional delivery methods and routes of administration

Roberta Antonia Diotti, Giuseppe Andrea Sautto and Valeria Caputo