Porphyrins in Tumor Phototherapy

ISBN-13: 9781468447231 / Angielski / Miękka / 2012 / 466 str.

R. Cubeddu

Opis

This book contains the contributions of the participants to the International Symposium on Porphyrins in Tumor Phototherapy held in Bruzzano (Milano), Italy on May 26-28, 1983. The contributions are written as extended papers to provide a broad and representative coverage of the use of porphyrins in tumor phototherapy and diagnosis. In the last few years, this technique has received increasing interest for its potential applications in clinical oncology. In fact, 1,500 patients have been already treated by this therapy which has been tested in more than 100 clinical centres. Among the reported cases, a significant therapeutic effectiveness was found in some early stage cancers of lung, esophagus and stomach. The development of -this therapy requires interdisciplinary studies from such diverse fields as physics, chemistry, biology, pharmacology, and experimental and clinical oncology. The contents of the book reflect the character of this research and deal with all the problems, from fundamental to clinical, that still require to be analysed and understood for a better evaluation 'of the potential of this therapy. The first chapter of the book deals with photophysics ?;nd.

Spis treści

I: Physics and Chemistry of Porphyrins and Related Compounds.- Excited State Properties of Haematoporphyrin.- Fluorescence Properties of HpD and its Components.- The Structure of the Active Component of Hematoporphyrin Derivative.- Photophysical and Photosensitizing Properties of Photofrin II.- On the Purification of Hematoporphyrin IX and its Acetylated Derivatives.- Photosensitizing Properties of Porphyrin in Model Cell Systems.- Photosensitizing Properties of Free and Bound Uroporphyrin I.- Chemical and Biological Studies on Haematoporphyrin Derivative: An Unexpected Photosensitization in Brain.- A Chromatographic Study of Hematoporphyrin Derivatives.- Protection by Carotenoids from Singlet Oxygen Photoproduced by Porphyrins.- Effect of He-Ne Laser on Human Erythrocytes Incubated with Hematoporphyrin Derivative and Bonellin: Comparative Study.- Survey of Potential PRT Dyes and their Spectroscopic Properties.- II: Interactions of Porphyrins with Model Systems and Cells.- Fluorescence of Porphyrins in Cells.- Hematoporphyrin Derivative: Fluorometric Studies in Solution and Cells.- Time-Resolved Laser Fluorescence and Photobleaching of Single Cells after Photosensitization with Hematoporphyrin Derivative (HpD).- Effects of Hpd and Laser on Transformed and Corresponding Normal Cultured Cells: Differential Cytotoxicity as an in Vitro Model for Tumor Photochemotherapy.- Interaction of Free and Liposome-Bound Porphyrins with Normal and Malignant Cells: Biochemical and Photosensitization Studies in Vitro and in Vivo.- Photodynamic Inactivation of L929 Cells after Treatment with Hematoporphyrin Derivative.- Bacterial and Yeast Cells as Models for Studying Hematoporphyrin Photosensitization.- Cholesterol Impregnation into Erythroleukemia Cell Membrane Induces Resistance to Hematoporphyrin Photodynamic Effect.- Photodynamic Effect of the He-Ne Laser with HpD on the Ultrastructure of Rhabdomyosarcoma Cell.- III: Studies on Experimental and Spontaneous Animal Tumors.- Hematoporphyrin Derivative Phototherapy in Experimental Oncology.- Photoradiation Therapy (PRT) of Lewis Lung Carcinoma in B6D2 Mice, Dosimetry Considerations.- Study of Irradiation Parameters in HpD Phototherapy of MS-2 Tumor Model.- Experimental ENU Induced Brain Tumors with HpD and Dye Laser Light.- Studies with Hematoporphyrin Derivative in Transplantable Urothelial Tumors.- Time Dependence of 3 H Hematoporphyrin Derivative Distribution in the Digestive Tract of the Rat.- Nd YAG Destruction of Tumor Sensitized or Non Sensitized by HpD.- HpD Phototherapy on Spontaneous Tumors in Dog and Cat.- IV: Light Dosimetry and Instrumentation for Tumor Diagnosis and Phototherapy.- Thermal and Optical Dosimetry for Photoradiation Therapy of Malignant Tumors.- Photophysics and Dosimetry of Photoradiation Therapy.- An Optimised Laser System for the Evaluation of HpD Therapy.- A Multi-Led Source for Photoradiation Therapy.- Side Radiation Optical Fibers for Medical Applications.- Fluorescence of Hematoporphyrin-Derivative for Detection and Characterization of Tumors.- In Vivo Fluorescence Excitation Spectra of Hematoporphyrin-Derivative (HpD).- In Vivo Observation of Porphyrin and of the Light Action.- Monitoring of Hematoporphyrin Injected in Humans and Clinical Prospects of its Use in Gynecologic Oncology.- V: Clinical Applications of HpD Phototherapy.- Hematoporphyrin Derivative Photoradiation Therapy, in Theory and in Practice.- Evaluation of Photoradiation Therapy (PRT) in 20 Cases of Cancers.- Hematoporphyrin Phototherapy of Malignant Tumors.- Hematoporphyrin-Derivative and Phototherapy in Extensive Basal-Cell Carcinoma of the Dorsal Skin.- Hematoporphyrin Derivative Photoradiation Therapy of Endobronchial Lung Cancer.- Photoradiation Therapy in Early Stage Cancer Cases of the Lung, Esophagus and Stomach.- Experimental and Clinical Studies on HpD-Photoradiation Therapy for Upper Gastrointestinal Cancer.- Endoscopic HpD-Laser Photoradiation Therapy (PRT) of Cancer.- Dye-Laser Photoradiation-Therapy of Bladder Cancer after Photosensitization with Hematoporphyrin Derivative (HpD)-Basis for an Integral Irradiation.- Photoradiation Therapy with Hematoporphyrin Derivative and an Argon Dye Laser of Bladder Carcinoma.- Preclinical Examination of Ocular Photoradiation Therapy.- Photoradiation for Choroidal Malignant Melanoma.