Polypharmacy in Psychiatry Practice, Volume I: Multiple Medication Use Strategies

ISBN-13: 9789400758049 / Angielski / Twarda / 2013 / 287 str.

Michael S. Ritsner

Opis

Although monotherapy is generally recommended as the treatment of choice, treatment resistance of patients with psychosis, cognitive, mood and anxiety disorders represents a significant clinical problem. In this context, augmentation and combination strategies are commonly employed to address this problem. Although multiple medication use common in psychiatric practice, reasons, efficacy and safety for polypharmacy, and augmentative strategies have remained unclear. It remains unclear if there is an evidence base to support polypharmacy. Furthermore, excessive and inappropriate use of psychotropic medications has been recognized as a public health problem. This volume setis the first comprehensive, clinically oriented, reference on the multiple medication use to treat psychotic, cognitive, mood and anxiety disorders."

Recenzje

From the reviews:
"This is part of a two-volume set that is the first comprehensive, clinically oriented reference that looks at the evidence regarding the use of multiple medications in the treatment of a variety of mental illnesses. ... should be read by anyone involved in the pharmacological management of psychiatric illnesses." (Michael Easton, Doody's Book Reviews, July, 2013)

Spis treści

About the Editor

Preface 

Contributors

Part I. Polypharmacy treatment strategies

1. Multiple medication use in psychiatry: How Rational Can It Be? Ahsan Khan and Sheldon Preskorn

2. Receptor binding targets for antipsychotic efficacy; Maureen M. Grainger, Rebecca Ahlbrand, Paul S. Horn, Neil M. Richtand

3. Drug interactions and polypharmacy; Jessica L. Gören, and Ashley Tewksbury

4. Preclinical and clinical investigation of antipsychotic polypharmacy: What is the evidence? Dimitrios Kontis, Eirini Theochari

5. Should high dose or very long-term antipsychotic monotherapy be considered before antipsychotic polypharmacy? Stephen M. Stahl and Debbi A. Morrissette

6. Multiple Medication Use of Neuropsychiatry in Forensic Psychiatry: Findings from the Central State Forensic Psychiatric Hospital of Saxony-Anhalt; Joachim G. Witzel

Part II. Augmentation strategies

7. Antipsychotic treatment within a naturalistic trial - how are we treating schizophrenia patients in the "real-world"? Rebecca Schennach, Michael Obermeier, Florian Seemüller, Daniela Krause, Richard Musil, Ilja Spellmann, Hans-Jürgen Möller, Michael Riedel

8. A multi-target drug treatment in schizophrenia using adjunctive agents with non-D₂ mechanisms of action; Michael S Ritsner

9. Antidepressants in schizophrenia – a place for them? Viacheslav Terevnikov and Grigori Joffe

10.  Stressful life events and anticonvulsant medication in psychiatric patients; Petr Bob

11.  Multiple medication use in somatic symptom disorders: from augmentation to diminution strategies; Adrian P. Mundt

Appendix; Rena Kurs

Annotated bibliography on polypharmacy

List of Psychotropic Medications  

Contents to Volume II

Contributors to Volume II

Index

Blurb

Despite the large number of psychotropic medications currently available, effective management of mental disorders continues to be a challenging task. Although monotherapy may be desirable, most patients require combinations of two or more psychotropic drugs. Polypharmacy aims to address different aspects of treatment resistance, especially insufficient response of positive and negative symptoms, cognitive disturbances, affective comorbidity, obsessive-compulsive syndromes and side-effects of antipsychotic agents. At the same time, evidence based guidelines in support of polypharmacy, and augmentative strategies are scant.

This two-volume collection is the first comprehensive, clinically oriented, reference text on polypharmacy (co-administration of more than one medication) or the use of multiple preparations to treat psychotic, cognitive, mood and anxiety disorders. This collection is divided into four parts.

Volume I contains two parts including chapters that serve as an introduction and overview of conceptual issues. Key topics include: rational polypharmacy, receptor binding targets, drug interactions, preclinical and clinical investigations in this field, dosing regimens, multiple medication use in forensic psychiatry, a naturalistic trial, adjunctive strategies, and multiple medication use for the treatment of somatic symptom disorders.

Volume II contains two parts that focus on antipsychotic polypharmacy for schizophrenia, and clinical practice in the USA, Czech Republic, Ukraine, and Italy, polypharmacy and associated phenomena, clozapine combinations and the metabolic syndrome. The authors discuss combination therapy for bipolar disorder, major depressive disorder, obsessive-compulsive syndromes in schizophrenia, and potentially inappropriate medication use among elderly patients with dementia.

Finally, each volume includes Appendix contains ‘Annotated bibliography on polypharmacy’ and ‘List of Psychotropic Medications’.