Polymers in Medicine: Biomedical and Pharmacological Applications

ISBN-13: 9781461576457 / Angielski / Miękka / 2012 / 420 str.

Emo Chiellini;Paolo Giusti

Opis

This book contains the collected papers presented at the Inter national Symposium on Polymers in Medicine, Biomedical and Pharma cological Applications, which was held at Porto Cervo, Italy, May 24-28, 1982. To the best of our knowledge, this symposium was the first to be organized in Italy entirely devoted to the several aspects of the use of synthetic and semisynthetic macromolecular materials in the field of biomedical and pharmacological applications. The inten tion of the Organizing Committee of the symposium was the promotion of a scientific and cultural initiative to gain the attention of various experts in line research of the potential of suitably de signed "man-made" polymeric materials in biomedical applications. With highly qualified and worldwide attendance, the above goal was fully satisfied. Indeed the opportunity of meeting to gether in a well conceived and discreet corner of the world, scien tists with different cultural backgrounds and objectives helped ex tend the meaning of the symposium far beyond the Italian borders and the perspectives of the National Research Council of Italy (CNR), the major sponsor of the meeting."

Spis treści

Section I Polymeric Drugs and Drug Delivery Systems.- Characteristic Bilolgical Effects of Anionic Polymers.- Polymeric Antitumour Agents on a Molecular and on a Cellular Level?.- Utilization of Stabilized Forms of Polynucleotides.- Application of the Congener Approach to the Design and Synthesis of Peptide-Catecholamine Conjugates.- New Polymeric and Oligomeric Matrices as Drug Carriers.- Development of N-(2-Hydroxypropyl)Methacrylamide Copolymers as Carriers of Therapeutic Agents.- Biologically Active Compounds Immobilized on Cellulose Derivatives.- Preparation of Enzyme Polymers for Therapeutical Use! Preliminary “In Vivo” Study.- Synthesis and Characterization of Covalently Bound Polymer-Hormone Conjugates for the Controlled Release of Hormones.- Improved Drug Delivery to Target Specific Organs Using Liposomes as Coated with Polysaccharides.- Synthesis and Release of Contraceptive Steroids from Bioerodible Poly(Ortho Ester)s.- Press-Coated Systems for Drug Release Control.- Polymeric Ophthalmic Drug Delivery Systems! Preparation and Evaluation of Pilocarpine-Containing Inserts.- Basic Physical Parameters of Polymeric Matrices Influencing Drug Release.- Section II Polymers as Biomaterials.- Polymers in Medicine-An Overview.- Functional Polyesters and Polyamides for Medical Applications of Biodegradable Polymers.- Polyurethanes as Biomaterials — Assessment of Blood Compatibility.- Synthesis, Structural Study and Preliminary Hemocompatibility Tests of AB and ABA Block Copolymers with Polyvinyl and Polypeptide Blocks.- Interactions of Some Plasmatic Proteins with Anticoagulant Polystyrene Resins! Mechanism of Catalytic Activity towards the Thrombin-Antithrombin Reaction.- Characterization and Albumin Adsorption on Surface Oxidized Polyethylene Films.- Radiation Induced Modification of Polyetherurethane Tubes with HEMA and Acrylamide.- Improvement of the Biocompatibility of Polymers through Surface Modification.- Physical Characterization of Poly(2-Hydroxyethylmethacrylate) Gels: Effect of the Diluent Content on the Mechanical and Transport Properties.- Section III Medical and Surgical Applications of Polymers.- The Design of a Small Diameter Arterial Replacement.- The Development of Small Diameter Vascular Prostheses.- Testing Devices for the Evaluation of Prosthetic Heart Valves.- Development and Testing of a New Prosthetic Heart Valve.- Heparin-like Substances and Blood-Compatible Polymers Obtained from Chitin and Chitosan.- Advances in the Development of Extraction Resistant Flexible PVC Compounds.- Immobilization of Enzymes on Hollow Fibers Assembled after Chemical Modification.- Polymer Composite Materials in Orthopaedic Surgery.