Pluripotent Stem Cell Therapy for Diabetes

ISBN-13: 9783031419423 / Angielski

Lorenzo Piemonti; Jon Odorico; Timothy J. Kieffer Kieffer

Spis treści

 

Development and differentiation of beta cells

Mimicking pancreas development with human pluripotent stem cells

Doug Melton, Harvard University

Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming.

Francesca Spagnoli, King's College London

Julie Sneddon, UCSF

The evolution of methods for in vitro differentiation of stem cell derived islets

Nathaniel HogrebeJ effrey Millman, Washington University

Signaling pathways that govern the formation, expansion and maturation of pancreatic progenitors

Cristina Nostro, University of Toronto

Building islets from the ground up using stem cells

Quinn Peterson

Pancreatic progenitor proliferation

Kenjy Osafune, University of Tokyo (Cira)

 

Bioengineering

Selecting biocompatible biomaterials for stem cell derived islet transplantation

Aart van Apeldoorn, Mastricht University

 

Scaffolds for encapsulation of stem-cell-derived β cells

Daniel G. Anderson, MIT

 

3d printing of new islets

Hanne Scholz, University of Oslo

Biological scaffolds and hydrogels in islet organoids

Ekaterine Berishvili, University of Geneva

3-D organoids of mesenchymal stromal and pancreatic islet cells

Westenfelder Chris, University of Utah

Bioengineered insulin producing endocrine tissues

Antonio Citro, Daniel Tremmel, Lorenzo Piemonti, Jon Odorico

Bioactive materials for cell encapsulation

Cheri Stabler, University of Florida

Strategies to boost islet graft oxygenation

Klearchos Papas, Arizona University

Vascularizing device strategies

Corinne Hoesli, McGill University

 

Immunoescape

Immunogenicity of stem cell derived islets

Van der Meulen, Bart Roep, Daniel Pipeleers

Immune evasive stem cell islets

Nostro, Misra, Odorico, Sackett

Encapsulation of stem cell-derived islets: recent progress

Lonnie Shea, University of Michigan

Hubert Tse or Mark Poznansky or both

Islet immunoengineering

Alice Tomei, University of Miami

Stem cell genome editing tools

Knut Woltjen, Kyoto University

 

Preclinical model and translational approaches

Selection of SC-derived pancreatic progenitors and β cell

Jacqueline Ameri, University of Copenhagen

 

Considerations pertaining to implant sites for cell-based insulin replacement

James Shapiro, University of Alberta

Safety switches in pluripotent stem cells

Andras Nagy, PanCella and Lunenfeld-Tanenbaum Research Institute

Safety: teratoma risk

Sordi and Piemonti

 

Stem cell derived islets transplantation in non-human primates

Hongkui Deng, China

 

 

 

 

Beta cell replacement: clinical horizon

Social / Legal / Ethical issues pertaining to use of pluripotent stem cells

Tim Caulfield, University of Alberta

Cost-effectiveness considerations for stem cell derived islet replacement therapy

Chris McCabe, University of Alberta

Lessons from clinical trials of islet cell replacement

Thierry Berney, Geneva

Francois Patou, Lille

David Thompson, University of British Columbia

Scale up and Biomanufacturing of Stem Cell- derived Islets

Michael Kallos, University of Calgary

Minimal SC-β cell properties for transplantation in diabetic patients

Matthias Hebrok, University of California

James Johnson, University of British Columbia

Autologous stem cell islets for patients with chronic pancreatitis and diabetes

Albert Hwa

Clinical Trials

Kieffer, Pagliuca, Kroon, Keymuellen, other Vertex personnel

Disease modeling

Modeling monogenic diabetes with stem cells

Timo Otonkoski, University of Helsinki

Stem and progenitor cells in pancreas development, regeneration and drug screening

Heiko Lickert, Helmholtz Munich

O autorze

Lorenzo Piemonti, M.D., is Professor of Endocrinology at the University of Vita-Salute San Raffaele. He specializes in the field of diabetes and pancreatology, with a particular focus on diabetes therapy and pathophysiology, regenerative medicine, and pancreatic cancer. Dr. Piemonti has extensive experience and expertise in beta cell replacement, immune tolerance induction strategies, dendritic cell biology, and stem cells. His research contributions have significantly advanced our understanding of these areas and their implications for diabetes management.

 

Jon S Odorico, M.D., is a distinguished Professor of Surgery in the Section of Kidney and Pancreas Surgery and Division of Transplantation at the University of Wisconsin School of Medicine and Public Health. He is renowned for his expertise in transplantation, including islet transplantation and pancreatology. Dr. Odorico's research and clinical work have made substantial contributions to the field, particularly in the area of pancreatic islet transplantation and its role in treating diabetes.

 

Timothy Kieffer, Ph.D., is a Professor in the Department of Cellular and Physiological Sciences at the University of British Columbia. His research focuses on understanding the physiology of pancreatic beta cells and developing innovative approaches for beta cell replacement therapy. Dr. Kieffer's expertise in beta cell biology and regenerative medicine has significantly contributed to the advancement of diabetes research and the development of potential treatments for diabetes.

 

Valeria Sordi, Ph.D., serves as a Group Leader in Beta Cell Differentiation in the Diabetes Research Institute at IRCCS Ospedale San Raffaele. Her research is centered on the differentiation of beta cells and their significance in diabetes treatment. Dr. Sordi's work contributes to the development of strategies for beta cell replacement and regeneration, with the aim of improving outcomes for individuals with diabetes.

 

Eelco de Koning, M.D., Ph.D., is a Professor of Diabetology at the Leiden University Medical Center. His expertise spans various aspects of diabetes, including islet transplantation and beta cell replacement therapy. Dr. de Koning's research and clinical experience have significantly advanced our knowledge of diabetes management and treatment options, with a focus on optimizing outcomes for patients with diabetes.

 

These authors, with their specialized knowledge and extensive contributions in the field of diabetes and pancreatology, bring invaluable expertise to the book. Their diverse backgrounds and expertise ensure a comprehensive and multidisciplinary approach, enhancing the scientific rigor and impact of the research.

Blurb

This is a unique book containing comprehensive coverage of pluripotent stem cell therapies for the treatment of diabetes. The greatest enthusiasm for treatment lies in the possibility of using stem cells to overcome the limits of islet transplantation. Organized into six parts, this book covers the development and differentiation of beta cells, bioengineering, immunoescape, preclinical model and translational approaches, beta cell replacement, and disease modeling. This is an ideal book for scientists, researchers, and clinicians working in the area of stem cell technology in the treatment of diabetes.