Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy: Proceedings of the Fifth International Symposium on Platinum and Other Metal C

ISBN-13: 9780898383584 / Angielski / Twarda / 1988 / 776 str.

Marino Nicolini

Opis

Proceedings of the Fifth International Symposium, held in Abano Terme (Padova), italy, June 29-July 2, 1987

Spis treści

A: Biochemistry of Platinum Complexes in Cancer Chemotherapy..- Kinetics of Formation of Genotoxic Platinum-DNA Lesions In Vivo.- The Role of Platinum-DNA Interactions in the Cellular Toxicity and Anti-Tumour Effects of Platinum Co-Ordination Compounds.- In Vivo Cis-Diamminedichloroplatinum(II)-DNA Adduct Formation and Removal as Measured with Immunochemical Techniques.- Oligonucleotide Modelling of Cis-Platinum Binding to DNA.- Macromolecular Antitumor Drugs: Pharmacology and Biology.- Unusual Hairpin-Like Conformations of Oligonucleotides Induced by Platinum Anti-Cancer Drugs.- Cisplatin-Radiation Interactions in Tumours and Normal Tissues.- Linkage Isomers of Platinum Complexes of Ant (2-amino-5-nitrothiazole) Differ in their DNA-Binding and Radiosensitization.- Competition between DNA and Orthophosphate for Coordination with Platinum(II) Complexes.- Effect of Cis-Diamminedichloroplatinum(II) on the Nucleotide Pool of Treated P388 Leukemia Cells.- Platinum Cytostatics Design Method Based on Topological Indices.- Kinetics of Changes in the Secondary Structure of DNA Induced by the Binding of Platinum Cytostatics.- The Influence of the 3?-Base on the Kinetics of the Binding of [PtCl(Dien)]Cl to the Dinucleotides D(GpH) (H = A,C,T).- In Vitro Repair of Cisplatin-DNA Adducts by a Defined Enzyme System.- Importance of DNA Sequence in the Reaction of d(ApG) and d(GpA) with Cis-Diamminedichloroplatinum (II).- Changes in UV-Absorbance are Due to Slow and Fast Conformational Rearrangements during DNA-Platination.- Visualization of Cisplatin-DNA and Carboplatin-DNA Adducts in Tissues and Cultured Cells.- Qualitative Investigation, Both In Vivo and In Vitro, of the Metabolites Formed by Cisplatin and Paraplatin Involving High Performance Liquid Chromatography Analysis.- B: Pharmacological Mechanisms and Toxicology of Platinum Complexes as Antitumor Agents..- Cisplatin Efficacy and Toxicity: Are They Separable?.- Mechanisms of Resistance to Platinum Drugs.- High Dose Cisplatin and Drug Resistance: Clinical and Laboratory Correlations.- Covalent Binding of Platinum to Kidney Subcellular Fractions from Guinea Pig Strains Sensitive or Resistant to Cisplatin Toxicity.- Inhibition of Platinum Drug Toxicity by Diethyldithiocarbamate.- Biochemical Modulation of Cisplatin.- Effects of Cisplatin and Carboplatin on Neurohypophysis, Parathyroid and their Role in Nephrotoxicity.- Cisplatin Uptake Mediated Cisplatin-Resistance in Human Ovarian Carcinoma Cells.- Integrated Polymerase and Exonuclease Activities of Escherichia Coli DNA Polymerase I on Platinated DNA.- Administration Route of Cis-Platinum Plays an Important Role in the In Vivo Pharmacokinetics.- Cytotoxicity of the Diethyldithiocarbamate Anion, of its S-Methylester and of Respective Platinum (II) Complexes.- Enzymuria in Cisplatin-Induced Kidney Damage as an Index of its Reversal by Combined Treatment with Diethyldithiocarbamate.- Biotransformations of Platinum Compounds with the 1,2-Diaminocyclohexane Carrier Ligand in Cultured L1210 Leukemia Cells.- The Relation between Phage Inactivation by and DNA-Binding of Pten (H2O)22+ and its Corresponding Bases at Different Acidities.- Protective Effect of Procaine Against Cisplatin Induced Nephrotoxicity in Mice.- Antitumor Activity and Toxicity of Selected Platinum Complexes.- The Interaction and Degradation of Xanthine Bases with Platinum Metals.- Interference of Thio-Compounds with Cis-Diammino-Dichloroplatinum (DDP) on Tumor Cells In Vitro.- A New Class of Hypoxic Cytotoxins [PtCl2 (NH3) (Nitroimidazole)].- Cisplatin Interactions with Reduced Glutathione: An In Vitro Study.- Determination of Platinum and Biologically Essential Trace Elements by Neutron Activation Analysis in Pharmacokinetic Studies on Cisplatin Derivatives with Estrophilic Ligands.- Synthesis and Therapeutic Effect of New Cis-Platinum Complexes on Experimental Tumors.- C: Clinical Applications of Platinum Complexes..- The Development of More Effective Platinum Therapy.- Platinum Radiosensitizers.- Platinum Coordination Derivatives by the Intraperitoneal Route: Pharmacokinetics and Clinical Results.- Chemotherapy of Head and Neck Cancer.- Different Platinum Schedules in the Treatment of Epithelial Ovarian Cancer.- Chemotherapy of Lung Cancer.- Platinum, the Synergistic Drug: From Clinical Evidence to Laboratory Suggestions.- Chemotherapy of Mammary Cancer with Anthracyclins and Alkylators.- The Pharmaceutical Stabilization of the Clinical Anticancer Drug Dach-Platinum-TMA (NSC271674).- A Clinical Study of Reduced Glutathione as a Protective Agent Against Cisplatin-Induced Toxicity.- Immunity in Patients Treated with Cis-Platinum.- Early and Progressive Glomerular Kidney Toxicity during Cis-Platinum Therapy.- Hepatic Arterial Infusion of Cisplatin as a Single Agent or in Combination with Vinblastine for Breast Cancer Metastatic to the Liver.- Comparison between a Human Small Cell Lung Carcinoma Cell Line (GLC4) and an Adriamycin (GLC4-ADR) and a CDDP (GLC4-CDDP) Resistant Subline. A Preliminary Report.- The Effect of Diethyldithiocarbamate (DDTC) on Response, Toxicity and Pharmacology of Cisplatin in Patients with Recurrent Squamous Cell Carcinoma of the Head and Neck.- Clinical Pharmacokinetics of (R)-(-)-1,1-Cyclobutane-Dicarboxylato-(2-Aminomethylpyrrolidine) Platinum(II) (DWA2114R).- Combination of Cisplatin and 5-Fluorouracil in the Treatment of Advanced Breast Cancer.- Antitumor Effects of High-Dose Cisplatin in Hypertonic Saline Against Human Ovarian Tumors Heterotransplanted in Nude Mice.- IP Versus IV Pharmacokinetics in Patients Using Radiolabelled Paraplatin.- D: Advances in Antitumor Research with Platinum and Non-Platinum Complexes; Development of New Metal Coordination Compounds: Synthesis and Characterization..- The Search for New Platinum Antitumor Agents: Progress, Problems and Prospects.- The Anticancer Activity of Metal Phosphine Complexes.- Platinum-Based Organometallic Complexes of Vitamin C and Related Analogs as Antitumor Agents.- A Coordination Chemical Approach to Prepare Organ-Specific Antitumor Platinum Complexes in Cancer Chemotherapy.- Metal-Coordination Chemistry with Biomolecules: Platinum-Nucleobase Interactions.- Chemical Considerations in the Design of Ruthenium Anticancer Agents.- Organometallic Titanocene and Ferricenium Complexes: Antitumor and Toxicologic Properties.- Modelling and Speciation of Metals Involved in Carcinogenesis and its Treatment.- Metal Complexes of Platinum Group: The Promising Antitumor Features of Cis-Dichlorotetrakis (Dimethylsulfoxide) Ru(II) [cis-RuCl2(Me2SO)4] and Related Complexes.- NMR Study of Properties in Solution of Platinum(II) Ammine-Aqua Complexes, Including Determination of Acid Dissociation Constants.- Studies on Ruthenium Nitroimidazoles Complexes as Radiosensitizers.- Platinum(II) Complexes with Alkylamines. Characterization and in Vitro Cytostatic Activity.- Antitumor Activity of Metal(II) Chelates of 2,2?-Bipyridyl-6-Carbothioamide: in Vitro Study.- Ternary Complexes of Pt+2 and Pd+2 with Ino, Guo and Amino Acids.- Synthesis and in Vitro Antineoplastic Activity of Diorganostannylene Derivatives of 2,6-Pyridine Dicarboxylic Acid.- Two New Water Soluble Platinum Complexes — CL 286, 558 and CL 287, 110.- Complexes of Water Soluble Polymers and Organoplatinum Compounds as Potential Time-Release Antitumor Formulations.- Preclinical Development and First Clinical Studies of Budotitane.- Antitumor Activity of a New Platinum Cytostatic, DWA2114R.- Bis(Uracil-)-Complexes of Cisplatin: Preparation, Protonation and Metal Binding.- Cis-Diphosphine Platinum(II) Complexes with Pyrimydil Nucleosides: Synthesis, Characterization and Structural Studies.- Antitumor Properties of Metal (II) Complexes of 2-Pyridine Carboxaldehyde 2?-Pyridylhydrazones and Related Compounds.- Metal Ions Complexation Properties of Antitumor Anthracyclines. Different Cyto and Cardiotoxicity of Copper(II) Chelates.- Cytostatic and Antitumour Properties for a New Series of Pt(II) Complexes with Cyclopentylamine.- 1-Methylcytosin-Complexes of Pt(IV).- Effects of Nickel-Lapachol in Hypoxic Cells.- Platinum(II) Complexes with Amides of Pyridinecarbonic Acids and Some Diamides.- Bidentate Hydroxycarboxylic Acid Platinum(II) Complexes with Antitumor Activity.- Structure, Magnetic Properties and Antineoplastic Activity of Novel Phthalato-Bridged Copper(II) Complexes.- Synthesis and Structure of the Tetra 5,6-Dihydropyrimidino[5,4-c] Carbazole Dichloride Hexachloroplatinate (IV) Tetrahydrate.- Antitumor Activity of Zindoxifene Derived Platinum Complexes.- Platinum (II) Complexes with Aminopyrimidines.- Author Index.