Platform Trial Designs in Drug Development: Umbrella Trials and Basket Trials

ISBN-13: 9780367732639 / Angielski / Miękka / 2020 / 304 str.

Zoran Antonijevic; Robert A. Beckman

Opis

Drug development sponsors cannot run individual trials for all products in all indications. This results in missed opportunities. Clinical trial programs known as “basket” and “umbrella” have demonstrated that multi-product, multi-indication trials can be efficient and feasible.

Spis treści

I. Overview of Platform Clinical TrialsIntroductionRobert A. Beckman and Zoran AntonijevicI-SPY2: Unlocking the potential of the platform trialLaura Esserman, Nola Hylton, Smita Asare, Christina Yau, Doug Yee, Angie Demichele, Jane Perlmutter, Fraser Symmans, Laura van’t Veer, Jeff Matthews, Don Berry, and Anna BarkerThe challenges with Multi-arm targeted therapy trialsRyan J. Sullivan and Keith Flaherty. Basket trials at the confirmatory stageRobert A. Beckman and Cong ChenHarnessing Real World Data to Inform Platform Trial DesignDaphne A. Guinn, Subha Madhavan, and Robert A. BeckmanImpact of Platform Trials on Pharmaceutical FrameworksZoran Antonijevic, Edward Mills, Jonas Häggström, and Kristian Thorlund. II. StakeholdersFriends of Cancer Research Perspective on Platform trialsJeff D. Allen, Madison Wempe, Ryan Hohman, and Ellen Sigal Regulatory and Policy aspects of Platform trialsRasika Kalamegham, Ramzi Dagher, and Peter Honig Multi-arm, multi-drug trials from a reimbursement perspectiveAnja Schiel, and Olivier CollignonHighly Efficient Clinical Trials: A resource-saving solution for global healthEdward Mills, J

O autorze

Zoran Antonijevic is Owner and Consultant of Z-Adaptive Design. He held executive positions in Pharmaceutical Companies and CROs and has designed more than 100 clinical trials in numerous therapeutic areas, many of which included adaptive designs. He has authored numerous papers and scientific presentations and edited Optimization of Pharmaceutical R&D Programs and Portfolios.

Robert Beckman is Professor of Oncology and of Biostatistics, Bioinformatics, and Biomathematics at the Lombardi Comprehensive Cancer Center and the Innovation Center of Biomedical Informatics, Georgetown University Medical Center. He has played significant leadership roles in developing new oncology clinical research groups at four pharmaceutical companies, while co-inventing several novel clinical and statistical development strategies. His versatile publication record comprises more than 250 contributions ranging from computational chemistry to clinical oncology.

The editors are past and current chairs of the Drug Information Association Adaptive Design Scientific Working Group, an international group of over 200 statisticians focused on novel clinical study designs and their role in bringing new medicines to patients.