Platelet Function: Assessment, Diagnosis, and Treatment

ISBN-13: 9781588292445 / Angielski / Twarda / 2005 / 398 str.

Martin Quinn; Martin Quinn; Desmond Fitzgerald

Opis

A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.

Recenzje

From the reviews:

"...an outstanding book for those who want a concise review of platelet function and its relevance to thrombotic disorders and current pharmacology." - Circulation

"...a very useful book for anyone interested in the fundamentals of platelet function, platelet biomarkers, techniques for activation measurement, and thrombotic disorders." - Circulation

"This book is directed to the attention of clinicians practicing clinical and or laboratory medicine, basic scientists interested in platelet physiology, pharmocologists focusing on cardiovascular drugs, and teachers of medical students and physicians in training. ... The most advanced investigative techniques are presented in separate chapters to explore platelet membrane receptors, signal-dependant translation in platelets and for identifying products that regulate thrombosis and inflammation. ... a relatively small book, but with 397 pages of pertinent and practical knowledge from major professionals in the field." (Harry L. Messmore and William H. Wehrmacher, Clinical and Applied Thrombosis/Hemostasis, Vol. 12 (1), January, 2006)

Spis treści

Part I. Platelet Physiology Platelet Physiology Martin Quinn Platelet Integrins and Signaling Karlheinz Peter Platelet Adhesion Brian Savage and Zaverio M. Ruggeri Structure-Function of the Platelet Cytoskeleton Elaine L. Bearer Platelets and Inflammation Meinrad Gawaz Platelet Signal-Dependent Protein Synthesis Stephan Lindemann, Thomas M. McIntyre, Stephen M. Prescott, Guy A. Zimmerman, and Andrew S. Weyrich Phosphoproteomics of Human Platelets Katrin Marcus and Helmut E. Meyer Part II. Assessing Platelet Function Platelet Function Studies Dermot Cox Platelet Function Under Flow José A. López, Ian del Conde, and Jing-Fei Dong Pharmacodynamics of GPIIb-IIIa Receptor Blockade Lisa K. Jennings and Melanie M. White Prostanoid Generation in Platelet Function: Assessment and Clinical Relevance Bianca Rocca and Carlo Patrono Platelets and Prothrombin Michael Kalafatis, Emil Negrescu, Tatiana Byzova, and Edward F. Plow Markers of Platelet Activation and Granule Secretion Alan D. Michelson and Mark I. Furman Genomic and Proteomic Analysis of Platelets: Clinical Applications Andrew Maree and James McRedmond Part III. Clinical Applications Antiplatelet Agents Jacqueline Saw and David J. Moliterno Assessing Platelet Function in Clinical Trials Neal Kleiman Index

Blurb

Platelet function, or clot formation, is difficult to assess, but extremely important because inadvertent or excessive platelet activation underlies many common cardiovascular disorders, such as myocardial infarction, unstable angina, and stroke. In Platelet Function: Assessment, Diagnosis, and Treatment, a panel of leading researchers and clinicians review the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.
Comprehensive and state of the art, Platelet Function: Assessment, Diagnosis, and Treatment offers vascular researchers and clinicians a sound foundation for understanding platelet biology, assessing thrombotic risk in patients, and determining the rational dosing of antiplatelet agents.