Phytochemical and pharmacological evaluation of different fractions of Lannea grandis Engl (Family: Anacardiaceae)

ISBN-13: 9783656699507 / Angielski / Miękka / 2014 / 136 str.

Sharmin Akhter

Opis

Master's Thesis from the year 2012 in the subject Pharmicology, course: Pharmacy, language: English, abstract: The present research work was conducted to investigate the phytochemical and pharmacological activities of the different fractions of Lannea grandis Engl. (Family-Anacardiaceae). In phytochemical screenings with the crude extractives demonstrated the presence of alkaloids, steroids, tannins, saponins and gum. The antibacterial and antifungal activities of the crude extracts were evaluated by the disc diffusion method against 4 Gram positive and 7 Gram negative pathogenic bacteria and 7 fungi using Ciprofloxacin and Fluconazole as standards, respectively. In the screening, ethanol extract of L. grandis showed varying degrees of antibacterial activities than other two fractions with % zone of inhibition ranging from 46.09-48.42%, with strong activity against B. subtilis and S. aureus. On the other hand, the ethanol extract of plant also revealed mild to moderate antifungal activity with highest zone of inhibition of 20.5mm against B. dermatitidis. The MICs of the extracts were found to be 15.625-250μg/ml for both bacteria and fungal species used in the screening. During screening for antidiarrhoeal and antidepressant properties at dose 400mg/kg, significant (p