Phytate to kill cancer: Interactions of phytic acid in cancer targets

ISBN-13: 9786139972449 / Angielski / Miękka / 2018 / 164 str.

Amitha Joy; S. Balaji

Opis

Phytic acid is extensively known for its anti-nutritional properties. The wide notion about this compound is to be changed totally. Hence, the study is focused on bringing out its potential as a drug molecule. The knowledge gained by understanding the binding efficacy of phytic acid and its analogues can help in the development of a new lead molecule. The antibacterial studies and cell line studies using HCT-15 confirmed the drugability. The potency of cancer drug targets can also be screened using docking studies. The entire work can bring out an effective lead molecule which maybe subjected to clinical trials. It is hypothesized that phytic acid and its derivatives having one or more of the following chemical functional groups such as the number of phosphates, phospho-diesters, charged phosphates, halogens, heavy atoms, steriocentred atoms, hydoxyl groups, hydrogen donors and acceptors, have an effect on the binding affinity towards the selected targets. Although, there are few reports to suggest the anticancer activity of PA, there is no work on its structure-activity relationship.

O autorze

Joy, Amitha
Dr. Amitha Joy is working as Assistant Professor at Sahrdaya college of engineering and technology, Thrissur. Dr. S.Balaji is currently working as Associate Professor (Senior scale) at Manipal Institute of Technology. He is a recipient of Young Scientist award in the year 2010-11 by the government of Karnataka.