Preface & Intro & Acknowledgements Richa Salwan Physiological aspects 1. Overview of extremophiles Richa Salwan and Vivek Sharma 2. Physiology of Extremophiles Richa Salwan and Vivek Sharma 3. Mechanism of resistance focusing on copper, mercury and arsenic in extremophilic organisms, how acidophiles and thermophiles cope with these metals Javiera Alejrandra Norambuena 4. Halotolerant microbes and their applications in sustainable agriculture Suprasanna Penna, Jayant Kulkarni, Sandeep Sharma and Ashish Kumar Srivastava 5. Halophilic microorganisms: interesting group of extremophiles with important applications in biotechnology and environment Lobna Daoud and Mamdouh Ben Ali 6. Overview of extremophiles and their food and medical applications Jane Ann Irwin 7. Applications of extremophiles in Astrobiology Rebecca S. Thombre, Parag A. Vaishampayan and Felipe Gomez 8. High-pressureAdaptation ofExtremophiles and Biotechnological Applications Philippe Oger, Judith Peters and Marta Salvador-Castell 9. Fructanogenic Halophiles: A new Perspective on Extremophiles Ebru Toksoy Oner, Gülbahar Abaramak and Onur Kirtel 10. Applications of sulfur-oxidizing bacteria Kavita Rana, Neerja Rana and Birbal Singh 11. Physiological and genomic perspective of extremophiles in high salt concentrations Preeti Mehta, Ashish Verma and Sachin Kumar Biotechnological aspects 12. Genome editing in extremophiles using CRISPR/Cas9 technology Vivek Sharma and Richa Salwan 13. Lipases/esterases from extremophiles: main features and potential biotechnological applications Luigi Mandrich and Valentina De Luca 14. Thermostable ThermoanaerobacterAlcohol Dehydrogenases And Their Use In Organic Synthesis Sean Michael Scully and Johann Orlygsson Sr. 15. Biotechnological platforms of the moderate thermophiles, Geobacillus species: notable properties and genetic tools Hirokazu Suzuki and Keisuke Wada 16. Thermophiles and Thermophilic Hydrolases Shilpi Ghosh and Khusboo Lepcha 17. Effects of single nucleotide mutations in the genomes of multi-drug resistant 19biofilm producing Pseudomonas aeruginosa Babu Ramanathan, Sanjay Gunabalan and Chew Jactty 18. Understanding the structural basis of adaptation in enzymes from psychrophiles Mahejibin Khan 19. Molecular and functional characterization of major compatible solute in Deep Sea halophilic actinobacteria of active volcanic Barren Island, Andaman and Nicobar Islands, India Balakrishnan Meena, Lawrance Anburajan and Ramalingam Kirubagaran 20. Antarctic microorganisms as a source of biotechnological products Fernanda Abreu and Tarcisio Correa 21. The Secretomes of Extremophiles Mazen Saleh and Eyad Kinkar 22. Carbonic anhydrase from extremophiles and their potential use in biotechnological applications Clemente Capasso and Claudiu Supuran 23. Understanding the Protein Sequence and Structural Adaptation in Extremophilic Organisms through Machine Learning Techniques Abhigyan Nath 24. Exploration of extremophiles genomes through metagenomics for hidden Biotechnological and future potential Pijush Basak, Arpita Biswas and Maitree Bhattacharyya 25. The Ecophysiology, Genetics, Adaptive Significance, and Biotechnology of Nickel Hyperaccumulation in Plants Anthony Logan Ferrero, Peter R. Walsh and Nishanta Rajakaruna