Physical Virology

ISBN-13: 9783031368141 / Angielski / Twarda / 2023

Opis

This book highlights key findings generated during the past years from the main disciplines that constitute Physical Virology, from theoretical physics and simulations to material sciences and vaccines development to structural biology. Each chapter is written by world-class scientists from these areas and is a comprehensive review of where this field stands, as well as the future of Physical Virology. The diversity in the formal training of these scientists results in solving common problems using very distinct approaches, which can produce surprising findings. The multi- and interdisciplinary nature of this field has created a remarkable community that aims at understanding how viruses work and how they can be used in material sciences, chemistry, and biomedicine. Furthermore, the development of Physical Virology has resulted in technological advances that have shaped other fields; for example, it would be impossible to think about the development of Cryo-EM to solve the structure of complex viruses with atomic resolution without the contribution of scientists that created the field of Physical Virology. In the past decade, there has been a great success in the generation of viral systems that can encapsulate drugs, non-viral genetic material, or nanoparticles, as well as in the chemical and genetical modification of virions. Without any doubt in the immediate future, some of these technologies will jump from the bench to the market, creating a revolution in translational and biomedical sciences. The book provides key perspectives for the field, derived from expert´s opinions.

Spis treści

1. Selection of viral capsids across environmental conditions / Antoni Luque Santolaria, San Diego State University / Confirmed. 

2. Molecular Mechanisms in HIV-1 Particle Assembly / Alan Rein, National Cancer Institute / Confirmed 

3. Virus biomechanics: a biological perspective / Mauricio G. Mauteu, Universidad Autónoma de Madrid / Confirmed 

4. Bacteriophage Lambda as a Nano Theranostic Platform. Carlos Catalano, University of Colorado

5. Mechanics of virons, Pedro de Pablo, Universidad Autónoma de Madrid

6. Assembly of virus-like-particles for the generation of novel vaccines / Mauricio Comas-Garcia / Sergio Rosales-Mendoza, Universidad Autónoma de San Luis Potosí / Confirmed

7. Viruses in motion: maturation of an eukaryotic virus /Roger Castells, University of California, Los Angeles / John Johnson, Scripps Institute La Jolla / George Lomonossoff, John Innes Centre / Confirmed

8. Norovirus capsid assembly, Charlotte Uetrecht, CSSB Hamburg /Confirmed

9. TBD, Trevor Douglas, Indiana University, Bloomington / Confirmed

10. Kinetics of virus assembly and disassembly /Roya Zandi, University of California, Riverside / Paul van der Schoot, Eindhoven Universty of Technology / Confirmed 

11. Exploiting the fluorescence properties of virus-like-particles, Bodgan Dragnea, Indiana University, Bloomington / Confirmed

12. Biochemical modification of plant-viruses, Manidipa Banerjee, Indian Institute of Technology, Delhi

13. Replicon RNAs and gene therapy, William M. Gelbart, University of California, Los Angeles

14. Self-assembly of protein-based polymers into virus-like-particles, Armando Hernández- García, Universidad Autónoma de México

O autorze

Dr. Mauricio Comas-Garcia is a Professor of Biology at the University of San Luis Potosi, Mexico. He holds a Ph.D. in Physical Chemistry from the University of California, Los Angeles. His research interests include the how viruses remodel cells, and the physical interactions that control assembly and genome packaging of RNA viruses. Dr. Comas-Garcia has published over 20 scientific articles in peer-reviewed journals and co-edited two books. His research activities focus on the assembly, genome packaging, and generation of virus-like-particles of viruses such as Zika, Chikungunya, and SARS-CoV-2.

Dr. Sergio Rosales-Mendoza is a Professor of Biotechnology at the University of San Luis Potosi, Mexico. He holds a Ph.D. in Molecular Biology, and his research interests include developing innovative vaccines by applying rational antigen design approaches and using innovative expression hosts and advanced antigen delivery vehicles. Dr. Rosales-Mendoza has published over 150 scientific articles in peer-reviewed journals (H index: 32) and edited/written four books. In addition, he has trained several Ph.D. and postdoctoral fellows. Viral diseases had been a main target in Dr. Rosales´ research activity, with an interest in developing attractive vaccine prototypes against HIV, CHIKV, ZIKV, and SARS-CoV-2.