Photostability of Drugs and Drug Formulations, 2nd Edition

ISBN-13: 9780367394103 / Angielski / Miękka / 2019 / 448 str.

Hanne Hjorth Tonnesen

Opis

Covering in vitro and in vivo aspects of drug photoreactivity, this book provides the background necessary for the planning of standardized photochemical stability studies as a part of drug development and formulation work. The second edition of a bestseller, it focuses on standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. With chapter authors drawn from an international panel of experts, the second edition has been completely revised and updated to emphasize the significance of information and knowledge on drug photoreactivity in a pharmaceutical context.

Spis treści

Introduction: Photostability Testing of Drugs and Drug Formulations - Why and How? Photophysical and Photochemical Aspects of Drug Stability. Standardization of Kinetic Studies of Photodegradation Reactions. Rationalizing the Photochemistry of Drugs. Technical Requirements and Equipment for Photostability Testing. Photostability Testing: Design and Interpretation of Tests on New Drug Substances and Dosage Forms. The Questions Most Frequently Asked. Inconsistencies and Deficiencies Which Exist in the Current Official Regulations Concerning the Photolytic Degradation of Drugs. Benefits and Adverse Effects from the Combination of Drugs and Light. In Vitro Screening of the Photoreactivity of Antimalarials. A Test Case. Screening of Dyes, Drugs and Dietary Supplements for Ocular Phototoxicity. Photochemical and Photophysical Methods Used in the Study of Drug Photoreactivity. Addressing the Problem of Light Instability During Formulation Development. Photostability of Parenteral Products. Photoactivated Drugs and Drug Formulations. Formulation Approaches for Improving Solubility and its Impact on Drug Photostability. Appendices.

O autorze

Hanne Hjorth Tønnesen