Photodynamic Therapy: Methods and Protocols

ISBN-13: 9781493957309 / Angielski / Miękka / 2016 / 296 str.

Charles J. Gomer

Opis

This authoritative guide provides the most comprehensive reference volume describing current preclinical and clinical applications and protocols for photodynamic therapy. It includes coverage of dosimetric procedures for measuring PDT doses and responses.

Spis treści

1. Introduction Thomas J. Dougherty 2. Death and Survival Signals in Photodynamic Therapy Michael Dewaele, Tom Verfaillie, Wim Martinet, and Patrizia Agostinis 3. Photodynamic Therapy and Cell Death Pathways David Kessel and Nancy L. Oleinick 4. Identification of MAPKinase Pathways Involved in COX-2 Expression Following Photofrin Photodynamic Therapy Marian Luna, Angela Ferrario, Sam Wong, and Charles J. Gomer 5. Metronomic PDT and Cell Death Pathways Gurmit Singh, Omar Alqawi, and Myrna Espiritu 6. How to Monitor NF-kB Activation after Photodynamic Therapy Isabelle Coupienne, Jacques Piette, and Sébastien Bontems 7. Application of 5-Aminolevulinic Acid and Its Derivatives for Photodynamic Therapy In vitro and In vivo Asta Juzeniene, Petras Juzenas, and Johan Moan 8. Hypoxia and Perfusion Labeling During Photodynamic Therapy Theresa M. Busch 9. Targeting the Tumor Microenvironment Using Photodynamic Therapy Combined with Inhibitors of Cyclooxygenase-2 or Vascular Endothelial Growth Factor Angela Ferrario and Charles J. Gomer 10. Photochemical Internalization (PCI): A Technology for Drug Delivery Kristian Berg, Anette Weyergang, Lina Prasmickaite, Anette Bonsted, Anders Høgset, Marie-Therese R. Strand, Ernst Wagner, and Pål K. Selbo 11. Photodynamic Therapy-Generated Cancer Vaccines Mladen Korbelik 12. Antimicrobial Photodynamic Inactivation and Photodynamic Therapy for Infections Liyi Huang, Tianhong Dai, and Michael R. Hamblin 13. Photodynamic Therapy of Bacterial and Fungal Biofilm Infections Merrill A. Biel 14. Calculation of Cellular Oxygen Concentration for Photodynamic Therapy In vitro Michael S. Patterson and Emma Mazurek 15. Fluorescent MolecularImaging and Dosimetry Tools in Photodynamic Therapy Brian W. Pogue, Kimberley S. Samkoe, Summer L. Gibbs-Strauss, and Scott C. Davis 16. Bifunctional Agents for Imaging and Therapy Ravindra K. Pandey, Nadine S. James, Yihui Chen, Joseph Missert, and Munawar Sajjad 17. Photodynamic Diagnosis and Therapy and the Brain Herwig Kostron 18. Photodynamic Therapy of Head and Neck Cancers Merrill A. Biel

Blurb

Biological interactions of visible light with photosensitizers have been studied for over a century while controlled clinical applications of light and photosensitizers to treat solid tumors, known as photodynamic therapy, have been evolving since the mid 1970’s. In Photodynamic Therapy: Methods and Protocols, leading PDT scientists and clinicians provide the first comprehensive collection of methods and protocols specifically related to relevant mechanistic, dosimetric, preclinical, and clinical procedures used in current PDT research. Reflecting the growing number of studies demonstrating that immunological, tumor microenvironmental, and vascular responses are all contributing to PDT treatment outcomes, the contents of this volume move beyond the more traditional PDT concepts in order to investigate the numerous signal transduction and cell death pathways involved. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Photodynamic Therapy: Methods and Protocols is an ideal guide for new investigators just starting out in PDT research as well as seasoned investigators changing the direction of their research with the intention of exploring this vital field of study.