Phosphate and Mineral Homeostasis

ISBN-13: 9781468452082 / Angielski / Miękka / 2012 / 553 str.

Shaul G. Massry; Michel Olmer; Eberhard Ritz

Opis

We are pleased to present to our readers the proceedings of the Seventh Internat ional Workshop on Phosphate and other Minerals which was held in Marsielle, France during September 1-4, 1985. It was hosted by Professor Michel Olmer, the Chief of the Divison of Nephrology in Hopital de la Conception of the University of D'Aix- Marsielle II. The workshop was attended by 250 scientists from 17 countries including Algeria, Austria, Belgium, Canada, Czechoslovakia, Democratic Republic of C'.ermany, Egypt, England, France, Israel, Italy, Japan, Spain, Switzerland and the United States of America. There were 28 invited presentations by leading scientists and 40 oral and 75 poster presentations selected from over 200 abstracts submitted to the Organizing Commi ttee. This meet ing provided an excellent opportuni ty for interested scientists from interrelated disciplines including nephrology, endcrinology, physiology, biochemistry and nutrition to get together and discuss recent advances in the field of phosphate and mineral metabolism.

Spis treści

I. Special Presentations.- High Energy Phosphate, Phospholipids and Calcium in Ischemic Renal Tubular Cell Injury.- Calcium, Cell Function and Cell Death.- Primary Hyperparathyroidism (PHP) Revisited.- II. Renal Handling of Phosphate.- Mechanisms of Ion Transport Regulation by Parathyroid Hormone: cAMP/Ca2+/Calmodulin and Phospholipid Dependent Phosphorylation.- Mechanisms of NAD Action in Regulation of Renal Brush Border Membrane Transport of Phosphate.- Interactions between Inorganic Phosphate and Energy Metabolism in Renal Cortical Tubules.- Regulation of Na-Phosphate Cotransport in Cultured Renal Epithelial Cells: Protein-Synthesis-Dependent and Protein-Synthesis-Independent Pathways.- Phosphorin, A Phosphate-Binding Hydrophobic Protein Isolated from Renal Brush Border Membranes.- Intrarenal Phosphate Reabsorption: Role of Nephron Heterogeneity..- Resistance to the Phosphaturic Effects of Parathyroid Hormone during Phosphate Conservation is Due to Enhanced Phosphate Reabsorption by the Pars Recta.- Brush Border Membrane Phosphate Transport Effects of Volume Expansion.- The Direct Effect of 1,25-Dihydroxycholecalciferol on Membrane Phospholipid Composition and Phosphate Transport.- Possible Role of Calcium in Parathyroid Hormone Action on Phosphate Transport in Rabbit Renal Proximal Tubules.- Calcium Stimulates Sodium-Dependent Phosphate Absorption in Rabbit Proximal Convoluted Tubules Perfused In Vitro.- Characteristics of Phosphate Transport Across the Basolateral Membrane of the Proximal Tubule: An In Vivo Study.- Renal Proximal Tubular Brush-Border Membrane Transport of Phosphate with Acute Acidosis.- Effects of Glucagon on Renal and Extrarenal Handling of Pi in Rodents: Evidence for Pi Mobilizing Activity.- III. Renal Handling of Calcium and Magnesium.- Calcium Transport by the Proximal Tubule.- Mechanisms of Calcium Transport in the Thick Ascending Limb of the Loop Henle.- Calcium Transport in the Distal Convoluted Tubule.- Renal Membrane Transport of Calcium.- Renal Tubular Disorders Associated with Hypocalciuria.- Renal Magnesium Wasting Disorders.- Role of PTH, Vitamin D and Bone Metabolism in Low Protein-Induced Hypercalciuria.- IV. Intestinal Absorption of Phosphate and Calcium.- Mechanism and Regulation of Intestinal Phosphate Transport.- Intestinal Absorption of Phosphate in Man: Effect of Drugs.- Mechanism of Phosphate Transport Adaptation in Rat Intestinal and Renal Brush Border Membranes.- Analysis of Calcium Transport in Rat Intestine.- Calcium Absorption in the Rat Colon Measured In Vivo.- Impaired Intestinal Calcium Transport in the Spontaneously Hypertensive Rat.- V. Bone Metabolism.- Cellular Mechanisms of Bone Remodeling Evaluated at the Intermediary Level of Organization of Bone.- The Local Regulation of Bone Remodeling.- Immune Cells and Bone Resorption.- Bisphosphonates Can Reduce Osteoclastic Bone Resorption by Two Different Mechanisms.- Comparison of Aluminum Related with Vitamin D Related Osteomalacia by Tetracycline Based Bone Histomorphometry.- Parathyroid Hormone and 1.25 Vitamin D3 Exert Opposite Effects on Bone.- Serum Bone GLA-Protein Compared to Bone Histomorphometry in Hemodialyzed Patients.- Effects of 1,25(OH)2D3 Administration on Serum Bone GLA Protein in Predialysis Chronic Renal Failure.- Skeletal Mass in Long Term Hemodialysis Patients.- VI. Parathyroid Hormone.- Parathyroid Hormone Antagonists Effective In Vivo.- Solubilization of a Guanine Nucleotide-Sensitive Parathyroid Hormone-Receptor Complex from Canine Renal Cortex.- Parathyroid Hormone Secretory Responses to Peroral Phosphate and Stimulability of Serum Levels of Carboxyl-Terminal Flanking Peptide (PDN-21) of the Human Calcitonin Gene by Calcium in NOrmal and Osteoporotic Patients.- Renal Adenylate Cyclase Stimulating Action of Normal and Oxidized Parathyroid Hormone (1–34).- Hypercalcemia of Malignancy.- Mechanism of the Hypocalcemic Agent WR-2721 and Its Acute and Chronic Application in Eu- and Hyperparathyroidism.- Determinants of Circulating Levels of 1.25(OH)2D3 (Calcitriol) in Primary Hyperparathyroidism (PHPT).- Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism.- Changes in Serum Calcium and Phosphorus Induced by Chronic Renal Failure in the Absence of Parathyroid Hormone.- VII. Minerals and Blood Pressure.- Theoretical Mechanisms of Dietary Calcium’s Antihypertensive Action.- Calcium as a Mediator of Salt Sensitive Hypertension.- The Effect of Calcium on Renin, Aldosterone and Prostaglandin Release.- Disturbed Phosphate Metabolism in Spontaneously Hypertensive Rats.- Participation of Various Brain Nuclei in the Altered Time Course of Genetic Hypertension in SHR Dependent on Changes in Calcium Metabolism.- Dissociation Between the Hypotensive Effect of Thiazides and Plasma Divalent Cations.- VIII. NEPHROLITHIASIS.- Urine Citrate and Calcium in Calcium Nephrolithiasis.- Influence of Oxalate on Calcium Oxalate Crystals Formation in Urine Oversaturation.- Therapeutic Modalities for the Prevention of Nephrolithiasis.- IX. Miscellaneous.- Factors Controlling the Intracellular Concentration of Orthophosphate (Pi) in Mammalian Cells.- Phosphate Transfer and 31P Nuclear Magnetic Resonance (NMR) Spectroscopy Pre and Post Hemofiltration (HF).- Regulation of Renal Na-K-ATPase: Effects of Aldosterone in Phosphate Depletion.- Effects of the Impairment of Renal Function and of the pH of Gastric Secretion on the Efficacy of Al(OH)3 to Reduce Serum Inorganic Phosphorus.- Effects of Different Insulin Administration Modalities on Vitamin D Metabolism of Insulin-Dependent Diabetic Patients.- Influence of Inorganic Phosphate on Glucose-Induced Insulin Release In Vitro.- Mechanism of Inhibition of Glycolysis by Vanadate.- Regulation of Na+/H+ Antiport in the Intact Renal Proximal Tubular Cell.- Interaction of Vitamin D-Metabolites with Adenylate Cyclase/Cyclic AMP System: A Biological Model of Controlled Regulation.- Dibutryladenosine 3’,5’-Cyclic Monophosphate (dBcAMP) Does Not Mimic the Action of Parathyroid Hormone (PTH) on Canine Proximal Tubular Basolateral Membrane Na+:Ca2+.- Phosphate Transport Through Placenta Brush Border Membrane.