Phenotypic Switching: Implications in Biology and Medicine

ISBN-13: 9780128179963 / Angielski / Miękka / 2020 / 1112 str.

Herbert Levine; Mohit Kumar Jolly; Prakash Kulkarni

Recenzje

"This is a very high-quality book that targets a developing area of biological research and fully fleshes it out thanks to excellent authorship. The volume is intended for a fairly narrow and select audience. It provides a comprehensive
overview of the field as it stands today." --Doody

Spis treści

1. The fundamentals of phenotypic plasticity

2. Rethinking the role of chance in the explanation of cell differentiation

3. Random walk across the epigenetic landscape

4. Maneuvering protein functions and functional levels by structural excursions

5. Prion-mediated phenotypic diversity in fungi

6. Bistability in virus - host interaction networks underlies the succes of hepatitis C treatments

7. Quantifyinh Waddington landscapes, paths, and kinetics of cell fate decision making of differentiation/development

8. The physics of cell fate

9. Disentangling the environmentally induced and stochastic development components of phenotypic variation

10. The evolution of cell differentiation in animals: biomolecular condensates as amplification hubs of inherent cell functions

11. Phenotypic switching and its evolutionary consequences

12. Cell-state organization by exploratory sloppy dynamics

13. Emergence of metabolic heterogeneity in cell populations: lessons from budding yeast

14. Stochastic phenotypic switching in endothelial cell heterogeneity

15. Regulation of phenotypic plasticity from the perspective of evolutionary developmental biology

16. Phenotypic plasticity and the origins of novelty

17. Niche construction and the transition to herbivory: Phenotype switching and the organization of new nutritional modes

18. NAture, nurture, and noise in bird song ontogeny as determinants of phenotypic and functional variation among dialects

19. Domestication as a process generating phenotypic diversity

20. The glycobiology of ovarian cnacer progression: phenotypic switches an microenvironmental influences

21.Epithelia-mesenchymal transition in cancer

22. Phenotypic switching and prostate diseases: a model proposing a causal link benign prostatic hyperplasia and prostate cancer

23. Phenotypic plasticty and lineage switching in prostate cancer

24. Implications of non-genetic heterogeneity in cancer drug resistance and malignant progression

25. Phenotypic plasticity: the emergence of cancer stem cells and collective cell migration

26. Adaptive phenotypic switching in breast cancer in response to matric deprivation

27. Phenotypic instability induced by tissue disuption at the origin of cancer

28. Evolutionary strategies to overcome cancer cell resistance ot treatment