Pharmacology of 5-Ht6 Receptors, Part II: Volume 96

ISBN-13: 9780123859020 / Angielski / Twarda / 2011 / 242 str.

Franco Borsini

Opis

The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized, and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors.

• Written by expert researchers
• Covers all published literature to date in the field of 5-HT6 receptors

Spis treści

1. The Central Role of 5-HT6 Receptors in Modulating Brain Neurochemistry Lee A Dawson
2. 5-HT₆ receptor memory and amnesia. Behavioral Pharmacology: Learning and Memory Processes Alfredo Meneses, Pérez-García G, Tellez R, Ponce-Lopez T and C Castillo
3. Behavioral Pharmacology: Potential Antidepressant and Anxiolytic Properties Anna Wesolowska, Magdalena Jastrzebska-Wiesek
4. The 5-Ht6 Receptor as a Target for Developing Novel Anti Obesity Drugs David Heal, Jane Gosden, and Sharon Smith
5. Behavioral and neurochemical pharmacology of 5-HT6 receptors related to reward and reinforcement. Gaetano Di Chiara, Valentina Valentini and Sandro Fenu
6. 5-HT6 Receptor Ligands and their Antipsychotic Potential Jørn Arnt and Christina Kurre Olsen
7. 5-HT6 Receptor Ligands as Antidementia Drugs Ellen Siobhan Mitchell

O autorze

Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy