Pharmacology and Pharmacokinetics

ISBN-13: 9781468420579 / Angielski / Miękka / 2012 / 388 str.

T. Teorell

Opis

This collection of papers by leading pharmacokineticists and pharmacolo gists is the proceedings of a conference held at the John E. . Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, October 30 to November 1, 1972. As part of its advanced study program, the Center conducts workshops, seminars, and conferences on topics related to the biomedical interests of the Scholars-in Residence. Professor Torsten Teorell came to the Center in 1970 as one of the first Scholars. In 1971 and 1972, he spent several months at the Center devoting his attention to contemporary problems in the application of pharmacoki netics to experimental and clinical pharmacology. As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937). Since the appearance of his original paper, pharmacodynamics, or pharmacoki netics, has become increasingly important as a tool for the study of drug action in patients. The translation of experimental pharmacological findings into therapeutic regimens is today increasingly dependent on ade qua te models of drug action. The purpose of the conference, of which this book is the proceedings, was to discuss contemporary findings in this important biomedical research field. The conference program was designed by Professor Teorell with the help of a small committee which included Drs. Edward R."

Spis treści

Classical Pharmacokinetics to the Frontier.- A Modern View of Pharmacokinetics.- Translation of Pharmacokinetics to Clinical Medicine.- Effect of Route of Adminstration on Drug Disposition.- Interspecies Scaling.- Animal Scale-Up.- Drug Metabolism in Normal and Disease States.- Drug Action: Target Tissue, Dose-Response Relationships, and Receptors.- Pharmacokinetics and Pharmacodynamics of Acetazolamide in Relation to Its Use in the Treatment of Glaucoma.- The Role of the Lungs in the Metabolism of Vasoactive Substances.- The Importance of Tissue Distribution in Pharmacokinetics.- Physiological and Physical Factors Governing the Initial Stages of Drug Distribution.- Target Organ Modification in Pharmacology: Reversible Osmotic Opening of the Blood-Brain Barrier by Opening of Tight Junctions.- Pharmacogenetics-Single Gene Effects.- Application of Pharmacokinetic Principles to the Elucidation of Polygenically Controlled Differences in Drug Response.- Immediate Immunologic Reactions: Noncytolytic Mediator Release and Cytolytic Cell Destruction.- Pharmacokinetic Studies with Amphetamines: Relationship to Neuropsychiatric Disorders.- A Pharmacokinetic Approach to the Treatment of Depression.- Kinetics of Drug-Drug Interactions.- Comparative Pharmacokinetics of the Anticoagulant Effect of Coumarin Drugs in Man and Rat.- Pharmacokinetics and Cancer Chemotherapy.- Concluding Remarks.