Pharmacological evaluation of acetyl-11-α-ketoβ-boswellic acid mediate

ISBN-13: 9786200314413 / Angielski / Miękka / 2019 / 124 str.

Muralidhar Yegireddy; Adilaxmamma Kaliki

Opis

Mastitis is an important economic disease-causing production loss in the dairy industry. Antibiotics are becoming ineffective in controlling mastitis due to the emergence of resistant strains requiring the development of novel therapeutic agents. In this study, the authors present the phytochemical synthesis of silver nanoparticles (AgNPs) with acetyl-11- -keto-betaboswellic acid and evaluation of their activity in Staphylococcus aureus induced murine mastitis. Boswellic acid-mediated AgNP (BANS) were oval, polydispersed (99.8 nm) with a minimum inhibitory concentration of 0.033 µg ml-1 against S. aureus, inhibitory concentration (IC50) of 30.04 µg ml-1 on mouse splenocytes and safe at an in vivo acute oral dose of 3.5 mg kg-1 in mice. Mastitis was induced in lactating mice by inoculating S. aureus (log10 5.60 cfu) and treated 6 h post-inoculation with BANS (0.12 mg kg-1, intramammary and ip), and cefepime (1 mg kg-1, ip). BANS treatment significantly (P < 0.05) reduced bacterial load, CRP, SOD, CAT activities and neutrophil infiltration in affected mammary glands. BANS could be a potential therapeutic agent for managing bovine mastitis.

O autorze

Yegireddy, Muralidhar
Dr Muralidhar Yegireddy is an Assistant Professor with six years of teaching and research experience in Veterinary Pharmacology and Toxicology at undergraduate and postgraduate levels. Proficient researcher in the fields of Nanotechnology, Toxicology and Medicinal plants with more than 10 international publications.