Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s: Perspectives for Research and Therapy in the Late 1990s

ISBN-13: 9783034872201 / Angielski / Miękka / 2012 / 520 str.

A. Claudio Cuello; Brian Collier

Opis

This volume arose from the scientific program of the XIIth International Congress of Pharmacology, held in Montreal, Canada, July 24-29, 1994. The scientific program included plenary lectures and symposia, in addition to poster presentations and colloquia. The abstracts of the Congress presentations were published as .supplement 1 of volume 72 by the Cana- dian Journal of Physiology & Pharmacology. The Congress organizers sought a more expansive treatment of the Congress proceedings and appointed Dr. A. Claudio Cuello to coordinate preparation of the present volume; Dr. Brian Collier was chair of the scientific program committee and, thus, also collaborated on this work. The objective that we pursued was to produce a volume of reasonable size which would feature all of the plenary lectures and symposia from those authors who agreed to participate. To this end, we solicited mini- reviews from plenary lecturers and asked symposia organizers to coordi- nate a single short-review covering the individual topics within their event. Those who accepted this challenge are evident in this volume. We express our gratitude to these authors for doing so, and for exercising considerable ingenuity in completing their task within a reasonable time.

Spis treści

Drug Receptors.- Molecular Studies of Glutamate Receptors.- GABA Receptor Pharmacology.- Serotonin Receptor Subtypes: Exploiting their Therapeutic Potential.- Peptide Receptor Antagonists.- Angiotensin Receptor Subtypes and their Pharmacology.- Foundations and Future of Molecular Pharmacology.- Signal Transduction.- Lipid Messengers and Protein Kinase C for Intracellular Signalling.- Mechanisms for the Regulation of Inositol Lipid Signaling and Calcium Homeostasis.- G-Protein-Linked Receptors and Tyrosine Kinase-Mediated Signal Transduction Pathways: A Mid-1990s Perspective, with Working Hypotheses.- Receptor-G Protein Effector Coupling: Coding and Regulation of the Signal Transduction Process.- Pharmacology of Ion Channels.- Novel Aspects of the Pharmacology of Calcium Channel Modulators.- Calcium Channels, Calcium Channel Antagonists and the Functioning of the Gastrointestinal Tract.- Aspects of Potassium Channel Modulation.- Drug Metabolism.- The Proliferating P450s: Providers of Polysubstrate Pharmacology.- Human Cytochromes P450: Regulation and Functional Variability.- Drug Conjugation: Diversity and Biological Significance.- Interethnic Differences in Drug Metabolism and Pharmacogenetics.- Dietary Effects on Drug Metabolism.- Neuropharmacology.- Neurotransmitter Functions of Mammalian Tachykinins: Substance P and Neurokinin A.- Molecular Events Underlying the Anti-Opioid Effect of Cholecys-tokinin Octapeptide (CCK-8) in the Central Nervous System.- Pharmacology of Excitatory Amino Acid Receptors.- GABA Receptors: Recent Advances.- Therapeutic Possibilities with Serotonergic Drugs.- The Pharmacology of Neurotrophic Factors.- New Perspectives in the Pharmacology of Parenchimal Brain Anoxia-Ischemia.- Pathophysiology and Future Pharmacotherapy of Chronic Pain.- Neurohormonal Systems Underlying Drug Addiction: Relevance for Treatment Strategies.- Molecular and Cellular Mechanisms in Neurosecretion.- Purines.- Role of Purines in the Central Nervous System.- Adenosine: Some Therapeutic Applications and Prospects.- Cardiovascular Pharmacology.- Endothelins: Recent Progress.- Drugs Directly Affecting the Arterial Wall.- Chronic Drug Treatment of Essential Hypertension.- Role of Potassium Channel Blockers in the Treatment of Cardiac Arrhythmias.- Nitric Oxide.- Nitric Oxide in the Cardiovascular System.- Role of the L-Arginine-NO-Cyclic GMP Pathway in NANC Neurotransmission.- Endocrine Pharmacology and Immunopharmacology.- Neuroendocrine Hormones and the Immune System.- Selected Aspects of the Immunopharmacology of Cytokines.- Targeted Therapy of Cancer and Autoimmune Diseases.- The Pharmacology of Gene Expression.- Antisense Therapeutics.- Pulmonary Pharmacology.- Molecular Mechanisms of Anti-Asthma Therapy.- Chemotherapy.- Membrane Transport of Anticancer Drugs and Drug Resistance.- Toxicology.- Importance of Individual Enzymes in the Control of Ultimate Carcinogens.- Molecular and Cellular Aspects of Chemical Carcinogenesis.- Alterations in Cell Signaling and Cytotoxicity.- Calcium-Dependent Mechanisms in Drug Toxicity and Cell Killing.- Liver Toxicity Mediated by Leukocytes and Kupffer Cells.- Regulatory Requirements for Drug Registration.- Harmonization of Drug Regulation and Trial Requirements: Clinical Pharmacological Aspects and Responsibilities.- Pharmacological Methods.- In Vivo Magnetic Resonance in Pharmacological Research.- Application of Cell Culture Systems to the Study of Drug Transport and Metabolism.- Instructional Methods.- Providing Quality Education in Pharmacology: The Affordable Options.