Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health

ISBN-13: 9783030648749 / Angielski / Miękka / 2022

Opis

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.

Spis treści

1. Mona Alidadi, Amirhossein Sahebkar, Saeid Eslami, Farveh Vakilian, Lida Jarahi, Maryam Alinezhad-Namaghi, Seyed Mostafa Arabi, Saba Vakili, Fariba Tohidinezhad, Yasaman Nikooiyan, Abdolreza Norouzy

Title: The effect of curcumin supplementation on pulse wave velocity in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial.

2. Abolfazl Amini, Parand Khadivar, Ali Ahmadnia, Morteza Alipour, Muhammed Majeed, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar

Title: Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer.

3. Seyed Reza Mirhafez, Mohsen Azimi-Nezhad, Maryam Dehabeh, Mitra Hariri, Ronika Danesh Naderan, Ali Movahedi, Mohammed Abdalla, Thozhukat Sathyapalan, Amirhossein Sahebkar

Title: The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-blind, Randomized, Placebo-Controlled Trial.

4. Mahdi Hatamipour, Tannaz Jamialahmadi, Mahin Ramezani, Sayyed Abolghasem Sajadi Tabassi, Luis E. Simental-Mendía, Mohammad Reza Sarborji, Maciej Banach, Amirhossein Sahebkar

Title: Protective effects of curcumin phytosomes against high-fat diet-induced atherosclerosis.

5. Amir Abbas Momtazi-Borojeni, Narges Amel Zabihi, Ramin Khameneh Bagheri, Muhammed Majeed, Tannaz Jamialahmadi, Amirhossein Sahebkar

Title: Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-fed Rabbits.

6. Melika Naji, Setareh Soroudi, Maryam Akaberi1, Amirhossein Sahebkar, Seyed Ahmad Emami

Title: Updated review on the role of curcumin in gastrointestinal cancers.

7. Neda Shakour, Ricardo Cabezas, Janneth González, George E. Barreto, Tannaz Jamialahmadi, Farzin Hadizadeh, Amirhossein Sahebkar

Title: Curcumin can bind and interact with CRP: an in silico study.

8. Hossein Zarrinfar, Mahsa Behnam, Mahdi Hatamipour, Amirhossein Sahebkar

Title: Antifungal activities of curcumin and difluorinated curcumin against clinical dermatophyte isolates.

9. Seyed Mojtaba Sohrevardi, Behrooz Heydari, Mahmoud Reza Azarpazhooh, Mohammad Teymourzadeh, Luis E. Simental-Mendía, Stephen L. Atkin, Amirhossein Sahebkar, Mojgan Karimi-Zarchi

Title: Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial.

10. Yunes Panahi, Ashraf Karbasi, Ghasem Valizadegan, Nayyereh Ostadzadeh, Sara Saffar Soflaei, Tannaz Jamialahmadi, Muhammed Majeed, Amirhosein Sahebkar

Title: Effect of Curcumin on Severity of Functional Dyspepsia; a Triple Blinded Clinical Trial.

11. Zinat Heidari, Marzieh Mohammadi, Amirhossein Sahebkar

Title: Possible mechanisms and special clinical considerations of curcumin supplementation in patients with COVID-19.

12. Milad Ashrafizadeh, Shima Tavakol, Reza Mohammadinejad, Zahra Ahmadi, Habib Yaribeygi, Tannaz Jamialahmadi, Thomas P. Johnston, Amirhossein Sahebkar

Title: Paving the road toward exploiting the therapeutic effects of ginsenosides: an emphasis on autophagy and endoplasmic reticulum stress.

13. Atena Mahdavi, Mohammad Bagherniya, Mohammad Sadegh Mirenayat, Stephen L. Atkin, Amirhossein Sahebkar

Title: Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: A clinical review.

14. Eduardo Luis Konrath, Marcelo Dutra Arbo, Bruno Dutra Arbo, Mariana Appel Hort, Elaine Elisabetsky, Mirna Bainy Leal

Title: Plants with anti-addictive potential.

15. Diana Lelli, Livio Cortese, Claudio Pedone

Title: Use of Plant-Derived Natural Products in Sleep Disturbances.

16. Fateme Gharibpour, Farinaz Shirban, Mohammad Bagherniya, Mohsen Nosouhian, Thozhukat Sathyapalan, Amirhossein Sahebkar

Title: The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: a comprehensive review.

17. Luca Liberale, Fabrizio Montecucco, Federico Carbone

Title: Pharmacological properties of the plant-derived natural products cannabinoids and implications for cardiovascular health.

18. Luis E. Simental-Mendía, Claudia I. Gamboa-Gómez, Fernando Guerrero-Romero, Mario Simental-Mendía, Adriana Sánchez-García, Mariana Rodríguez-Ramírez

Title: Beneficial effects of plant-derived natural products on non-alcoholic fatty liver disease.

19. Habib Yaribeygi, Stephen L. Atkin, George E. Barreto, Amirhossein Sahebkar

Title: Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats.

20. Bahareh Sadat Yousefsani, George E. Barreto, Amirhossein Sahebkar

Title: Beneficial Medicinal Plants for Memory and Cognitive Functions Based on Traditional Persian Medicine.

21. Zahra Boghrati, Sara Sabouri-Rad, Seyed Ahmad Emami, Mohsen Tahaghoghi Saber, Amirhossein Sahebkar, Zahra Tayarani-Najaran

Title: The use of medicinal plants for the treatment of alopecia in the Canon of Avicenna: an evidence-based review.

22. Leila Mohtashami, Mohammad Sadegh Amiri, Zahra Ayati, Mahin Ramezani, Tannaz Jamialahmadi, Seyed Ahmad Emami, Amirhossein Sahebkar

Title: Ethnobotanical uses, phytochemistry and pharmacology of different Rheum species (Polygonaceae): A review.

23. Zahra Ayati, Mahin Ramezani, Mohammad Sadegh Amiri, Amirhossein Sahebkar, Seyed Ahmad Emami

Title: Genus Rosa: A review of ethnobotany, phytochemistry and traditional aspects according to Islamic traditional medicine (ITM).

24. Sofia Salari, Mohammad Sadegh Amiri, Mahin Ramezani, Ali Tafazoli Moghadam, Sepideh Elyasi, Amirhossein Sahebkar, Seyed Ahmad Emami

Title: Ethnobotany, Phytochemistry, traditional and modern uses of Actaea racemosa L. (Black cohosh): A review.

25. Farshad Abedi Torbati, Mahin Ramezani, Reza Dehghan1, Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Neda Shakour, Sepideh Elyasi, Amirhossein Sahebkar, Seyed Ahmad Emami

Title: Ethnobotany, phytochemistry and pharmacological features of Centella asiatica: a comprehensive review.

26. Zahra Boghrati, Elaheh Zibaee, Zahra Ayati, Mohammad Sadegh Amiri, Mahin Ramezani, Tannaz Jamialahmadi, Seyed Ahmad Emami, Amirhossein Sahebkar

Title: Ethnomedicinal uses, phytochemistry and pharmacology of different Cichorium species (Asteraceae): A review.

27. Zahra Sobhani, Maryam Akaberi, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami, Amirhossein Sahebkar

Title: Medicinal species of the genus Berberis: A review of their traditional and ethnomedicinal uses, phytochemistry and pharmacology.

28. Yunes Panahi, Mojtaba Mojtahedzadeh, Atabak Najafi, Mohammadreza Gheini, Mohammad Abdollahi, Mohammad Sharifzadeh, Arezoo Ahmadi, Shiva Ganjali, Seyyed Mahdi Rajaee, George E. Barreto, Amirhossein Sahebkar

Title: Protective effects of intravenous magnesium sulfate in stroke patients receiving amiodarone: A randomized controlled trial.

29. Ricardo Cabezas, Amirhossein Sahebkar, Valentina Echeverria, Janneth Gonzalez, Ghulam Md Ashraf, George E. Barreto

Title: In silico identification of novel interactions for FABP5 (Fatty Acid-Binding Protein 5) with nutraceuticals: Possible repurposing approach.

O autorze

George E. Barreto earned his PhD in Neuroscience (2009) from Universidad Complutense Madrid (Spain) studying the effects of neurosteroids on reactive glia with aging. His post-doctoral training at Stanford University School of Medicine (2009-2011) focused on addressing the role of astrocytes activation following stroke and enhance astrocytic functions targeting neuronal protection. Dr. Barreto is currently a Lecturer in Cell Biology/Immunology at University of Limerick, Ireland. His research interests focus on deciphering the neuropathological mechanisms induced by accumulation of lipids in glial cells, identifying different mechanisms by which hormones can affect brain lipid metabolism and how lipids accumulation can induce neuroinflammation in absence of brain-synthesized estradiol. He is also interested in immune and neuroendocrine aspects of glial cells as a pathological mechanism in many neurological diseases. He has published over 200 peer-reviewed manuscripts, 12 book chapters, and participated as speaker in several international congresses/meetings.

Amirhossein Sahebkar received her Pharm.D and PhD (in Pharmaceutical Biotechnology) degrees from the Mashhad University of Medical Sciences (MUMS; Mashhad, Iran), and is currently serving as a faculty member at the Department of Medical Biotechnology (School of Medicine), and Biotechnology Research Center of MUMS, with an adjunct title at the Metabolic Research Centre, University of Western Australia (Perth, Australia). His research focuses on the investigation of novel lipid-modifying agents, including natural products, for the management of severe dyslipidemias (including familial hypercholesterolemia) and atherosclerotic cardiovascular disease. He has published over 800 publications on peer-reviewed international scientific journals, wrote several books and book chapters and presented numerous communications in international and national congresses. He is among ESI-listed top 1% of the world highly cited researchers in two fields: Pharmacology & Toxicology and Clinical Medicine. He is also a member of several national and international scientific committees and organizations.

Blurb

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal of this contributed volume is to present a comprehensive collection on most important therapeutic aspects of plant-derived natural products and their molecular mechanisms of action.