Pharmacogenomics in Drug Discovery and Development

ISBN-13: 9781588298874 / Angielski / Twarda / 2008 / 487 str.

Opis

Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention.

Recenzje

From the reviews:

"This volume in the Methods in Molecular Biology series covers pharmacogenomics in drug discovery. ... The book is intended for scientists in academic, industrial, and health care settings who are striving to transform disease treatment into disease prevention. ... The advanced technologies are presented in a very detail manner, even including step-by-step protocols. ... By covering topics from individual molecules to systemic diseases ... this book provides an overview of current knowledge on the use of pharmacogenomics in therapeutics of disease." (Xiaobo Zhong, Doody's Review Service, July, 2008)

Spis treści

Table of Contents 1. The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery Qing Yan 2. Applications of Microarrays and Biochips in Pharmacogenomics Gary Hardiman 3. Confounding in Genetic Association Studies and Its Solutions Donglei Hu and Elad Ziv 4. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg 5. Pharmacogenomics of Drug Metabolizing Enzymes and Drug Transporters in Chemotherapy Tessa M. Bosch 6. Pharmacogenomics of G Protein-coupled Receptor Signaling: Insights from Health and Disease Miles D. Thompson, David E.C. Cole and Pedro A. Jose 7. G Protein-coupled Receptors Disrupted in Human Genetic Disease Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, and David E.C. Cole 8. G Protein-coupled Receptor Pharmacogenetics Miles D. Thompson, Katherine A. Siminoivitch, and David E.C. Cole 9. Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders Hamid Mostafavi Abdolmaleky and Sam Thiagalingam 10. Pharmacogenomics in Alzheimer’s Disease Ramón Cacabelos 11. Pharmacogenetics of Asthma Gregory A. Hawkins and Stephen P. Peters 12. From SNPs to Functional Studies in Cardiovascular Pharmacogenomics Sharon Cresci 13. Pharmacogenomics in Gastrointestinal Disorders Michael Camilleri and Yuri A. Saito 14. Pharmacogenomics in Rheumatoid Arthritis Prabha Ranganathan 15. Cancer Pharmacogenetics Sharon Marsh 16. Pharmacogenomics in the Preclinical Development ofVaccines: Evaluation of Efficacy and Systemic Toxicity in Mouse Using Array Technology Karin J. Regnström 17.Pharmacogenomics in the Evaluation of Efficacy and Adverse Events during Clinical Development of Vaccines Lennart J. Nilsson and Karin J. Regnström

Blurb

Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body.  In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies.  Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. Although not in standard Methods in Molecular Biology™ series format, the book retains the practicality and usefulness of the highly successful series.

Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention.